Should cognition be screened in new-onset epilepsies? A study in 247 untreated patients.

Journal of Neurology
Juri-Alexander Witt, Christoph Helmstaedter

Abstract

The aim of our study was to assess cognition in newly diagnosed and untreated patients with epilepsy in order to determine the prevalence and the determinants of cognitive deficits at this early stage of the disease. A total of 247 untreated patients with newly diagnosed epilepsy underwent a brief test battery focusing on attention and executive functions (EpiTrack(®)) and memory (short form of the VLMT). In addition, the assessment included ratings of self-perceived deficits in attention and memory. Impairments in attention and executive functions were seen in 49.4 % of the patients and memory deficits in 47.8 %. Unimpaired performance in both domains was observed in 27.9 % of the cases. Self-perceived deficits in attention were only reported by 28.7 % of the patients, and 25.1 % of the patients complained of memory impairments. Lower education and a symptomatic, i.e., lesional, cause of epilepsy were associated with worse performance in attention and executive functions, whereas worse memory performance was related to generalized tonic-clonic seizures. Results indicate a high prevalence of cognitive deficits at an early stage of epilepsy, which calls for consideration in the daily clinical care. Patients appear to underreport...Continue Reading

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Citations

Dec 3, 2014·Epilepsy & Behavior : E&B·Christoph Helmstaedter, Juri-Alexander Witt
Feb 24, 2016·Neuroscience and Biobehavioral Reviews·L E M BreuerA P Aldenkamp
Mar 31, 2015·Epilepsy & Behavior : E&B·Sallie BaxendaleDominic Heaney
May 7, 2014·Acta Neurologica Scandinavica·J-A WittC Helmstaedter
Nov 29, 2015·Neurologic Clinics·Beth A Leeman-Markowski, Steven C Schachter
Aug 25, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Juri-Alexander WittChristoph Helmstaedter
Apr 30, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mariam Mettry HullCharles M Zaroff
Nov 23, 2013·Epilepsy & Behavior : E&B·Nicol RühleJohannes Rösche
Nov 20, 2012·Epilepsy & Behavior : E&B·Juri-Alexander Witt, Christoph Helmstaedter
Mar 25, 2015·Seizure : the Journal of the British Epilepsy Association·Juri-Alexander Witt, Christoph Helmstaedter
Jul 28, 2016·Epilepsy & Behavior : E&B·Klajdi Puka, Mary Lou Smith
Aug 19, 2016·Epilepsy & Behavior : E&B·Klajdi Puka, Mary Lou Smith
Oct 30, 2016·Acta Neurologica Scandinavica·L E M BreuerA P Aldenkamp
Jan 25, 2017·Current Opinion in Neurology·Juri-Alexander Witt, Christoph Helmstaedter
Jun 18, 2017·Epilepsy & Behavior : E&B·Adil HarroudDang Khoa Nguyen
Jun 7, 2013·Continuum : Lifelong Learning in Neurology·Leslie A Rudzinski, Kimford J Meador
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Apr 28, 2018·The Veterinary Record·Joshua WinterHolger Andreas Volk
Jul 8, 2017·Epilepsy Currents·Jong Woo Lee
May 31, 2018·Epilepsy Currents·Adriana Bermeo-Ovalle
Dec 5, 2017·Journal of the International Neuropsychological Society : JINS·Bruce HermannSarah Wilson
Jul 11, 2012·Nature Reviews. Neurology·David W Loring, Kimford J Meador
Apr 6, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Emma FosterPatrick Kwan
Dec 22, 2019·Brain and Behavior·Lei WangHuapin Huang
Dec 14, 2019·Brain : a Journal of Neurology·Sarah GourmaudDelia M Talos
Jun 14, 2020·International Journal of Public Health·Dominika JarčuškováZuzana Gdovinová
Nov 28, 2020·Epilepsy & Behavior : E&B·Christodouli LagogianniPanayiotis Patrikelis
Dec 29, 2020·Epilepsy & Behavior : E&B·Beth A Leeman-MarkowskiKimford J Meador
Feb 6, 2021·Epilepsy & Behavior : E&B·Agnes Balint BjørkeKjell Heuser
Apr 25, 2021·Brain & Development·Sofia KasradzeTamar Gagoshidze
Oct 19, 2019·Epilepsy & Behavior : E&B·H BrissartM Boutin

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