Should digestion assays be used to estimate persistence of potential allergens in tests for safety of novel food proteins?

Clinical and Molecular Allergy : CMA
Santiago Schnell, Rod Herman

Abstract

Food allergies affect an estimated 3 to 4% of adults and up to 8% of children in developed western countries. Results from in vitro simulated gastric digestion studies with purified proteins are routinely used to assess the allergenic potential of novel food proteins. The digestion of purified proteins in simulated gastric fluid typically progresses in an exponential fashion allowing persistence to be quantified using pseudo-first-order rate constants or half lives. However, the persistence of purified proteins in simulated gastric fluid is a poor predictor of the allergenic status of food proteins, potentially due to food matrix effects that can be significant in vivo. The evaluation of the persistence of novel proteins in whole, prepared food exposed to simulated gastric fluid may provide a more correlative result, but such assays should be thoroughly validated to demonstrate a predictive capacity before they are accepted to predict the allergenic potential of novel food proteins.

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Citations

Oct 31, 2009·Clinical and Molecular Allergy : CMA·Rod A HermanArvind Thirumalaiswamysekhar
Jan 10, 2012·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M DenisA Lachaux
Oct 30, 2016·Regulatory Toxicology and Pharmacology : RTP·Barry W SchaferRod A Herman

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