Abstract
Patients with atrial fibrillation (AF) are at risk of thromboembolic events. The CHA2DS2-VASc (congestive heart failure, hypertension, age 65-74, diabetes, female sex and vascular disease, which all count for 1 point, and previous transient ischemic stroke/stroke or age ≥ 75 years, which count for two points) score stratifies this risk and consequently indicates whether anticoagulation is required but leaves room for debate regarding patients with a CHA2DS2-VASc score of 1, irrespective of sex. A score of 1, irrespective of sex, is derived from varying risk factors and may represent different risks. We systematically searched PubMed from inception to July 31, 2017, for studies describing thromboembolic risk per risk factor of the CHA2DS2-VASc score in patients with AF not treated with an anticoagulant. Two independent reviewers selected, appraised, and extracted the data to determine the thromboembolic risk per risk factor. Per study, risk factors were ranked for highest through lowest risk. Five studies were included, comprising 37,030 subjects with a CHA2DS2-VASc score of 1. Numerically, the highest event rates were seen in patients without comorbidities, but aged 65-74 years, while event rates in patients with vascular disea...Continue Reading
References
Aug 28, 2003·JAMA : the Journal of the American Medical Association·Thomas J WangEmelia J Benjamin
Jun 20, 2007·Annals of Internal Medicine·Robert G HartMaria I Aguilar
Sep 19, 2009·Chest·Gregory Y H LipHarry J G M Crijns
Mar 20, 2010·Chest·Ron PistersGregory Y H Lip
Feb 2, 2011·BMJ : British Medical Journal·Jonas Bjerring OlesenChristian Torp-Pedersen
Apr 26, 2011·Atherosclerosis·Lian-Yu LinJiunn-Lee Lin
Jun 18, 2011·Chest·Jonas Bjerring OlesenGregory Y H Lip
Jan 17, 2012·European Heart Journal·Leif FribergGregory Y H Lip
Sep 29, 2012·European Heart Journal·Michiel CoppensStuart J Connolly
May 15, 2013·Chest·Stavros ApostolakisGregory Y H Lip
Jun 21, 2013·Journal of the American Heart Association·Daniel E SingerAlan S Go
Aug 24, 2013·European Heart Journal·Stavros ApostolakisGregory Y H Lip
Dec 10, 2013·Lancet·Christian T RuffElliott M Antman
Dec 18, 2013·Thrombosis and Haemostasis·S LahayeK Francis
Apr 2, 2014·Journal of the American College of Cardiology·Craig T JanuaryClyde W Yancy
Apr 18, 2014·Journal of Stroke·Bum Joon Kim, Jong S Kim
Jul 22, 2014·Pacing and Clinical Electrophysiology : PACE·Duo HuangChung-Wah Siu
Oct 18, 2014·Journal of the American College of Cardiology·Tze-Fan ChaoShih-Ann Chen
Jan 3, 2015·Systematic Reviews·David MoherUNKNOWN PRISMA-P Group
Jan 24, 2015·Journal of the American College of Cardiology·Leif FribergAndreas Terént
Feb 14, 2015·Journal of the American College of Cardiology·Tze-Fan ChaoShih-Ann Chen
Feb 5, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Chern-En ChiangShing-Jong Lin
Mar 18, 2016·PloS One·Yi-Hsin ChanChi-Tai Kuo
Mar 24, 2016·Journal of Internal Medicine·G Y H LipC Blomström-Lundqvist
Aug 26, 2016·Scientific Reports·Yu-Tao GuoGregory Y H Lip
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Jan 1, 2017·Revista Española De Cardiología·Paulus KirchhofPanagiotis Vardas