Should HLA mismatch acceptability for sensitized transplant candidates be determined at the high-resolution rather than the antigen level?

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
R J DuquesnoyA Zeevi

Abstract

Defining HLA mismatch acceptability of organ transplant donors for sensitized recipients has traditionally been based on serologically defined HLA antigens. Now, however, it is well accepted that HLA antibodies specifically recognize a wide range of epitopes present on HLA antigens and that molecularly defined high resolution alleles corresponding to the same low resolution antigen can possess different epitope repertoires. Hence, determination of HLA compatibility at the allele level represents a more accurate approach to identify suitable donors for sensitized patients. This approach would offer opportunities for increased transplant rates and improved long term graft survivals.

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Citations

Jan 20, 2016·Current Treatment Options in Cardiovascular Medicine·Robert M Cole, Jon A Kobashigawa
Mar 18, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J M CeckaA A Zachary
Jul 17, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R J DuquesnoyA Zeevi
Jun 18, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K J TinckamP Campbell
Jun 23, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D Glotz, A Tambur
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Feb 22, 2017·Transplantation·Malek KamounRobert M Merion
Dec 15, 2016·Frontiers in Immunology·Rene J Duquesnoy
Jan 11, 2017·Journal of Immunology Research·Edward J Filippone, John L Farber
May 17, 2017·Current Opinion in Organ Transplantation·Valia Bravo-Egana, Dimitri Monos
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Jan 10, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yanping HuangDimitri Monos
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Aug 9, 2021·Transfusion·Patricia A R BrunkerGrace K Mahowald

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