Should human papillomavirus vaccination target women over age 26, heterosexual men and men who have sex with men? A targeted literature review of cost-effectiveness

Human Vaccines & Immunotherapeutics
Nyi Nyi SoeLei Zhang

Abstract

Human papillomavirus (HPV) vaccination for young women up to age 26 is highly cost-effective and has been implemented in 65 countries globally. We investigate the cost-effectiveness for HPV vaccination program in older women (age > 26 years), heterosexual men and men who have sex with men (MSM). A targeted literature review was conducted on PubMed for publications between January 2000 and January 2017 according to the PRISMA guidelines. We included English-language articles that reported the incremental cost-effectiveness ratio (ICER) of HPV vaccination programs for women over age 26, heterosexual men, and MSM and identified the underlying factors for its cost-effectiveness. We included 36 relevant articles (six, 26 and four in older women, heterosexual men and MSM, respectively) from 17 countries (12 high-income (HICs) and five low- and middle-income (LMICs) countries). Most (4/6) studies in women over age 26 did not show cost-effectiveness ($65,000-192,000/QALY gained). Two showed cost-effectiveness, but only when the vaccine cost was largely subsidised and protection to non-naïve women was also considered. Sixteen of 26 studies in heterosexual men were cost-effective (ICER = $19,600-52,800/QALY gained in HICs; $49-5,860/QALY...Continue Reading

References

Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Nov 20, 2004·Emerging Infectious Diseases·Al V TairaGillian D Sanders
Mar 21, 2007·Emerging Infectious Diseases·Elamin H ElbashaRalph P Insinga
Nov 22, 2007·Gynecologic Oncology·Anna R Giuliano
May 28, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·E J DasbachE H Elbasha
Jul 22, 2008·BMJ : British Medical Journal·Mark JitW John Edmunds
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Apr 16, 2010·International Journal of Technology Assessment in Health Care·Jens Olsen, Martin Rudbeck Jepsen
Aug 18, 2010·Vaccine·Elamin H Elbasha, Erik J Dasbach
Jul 12, 2011·The Journal of Infectious Diseases·Tjalke A WestraJan C Wilschut
Aug 6, 2011·Vaccine·Harrell W ChessonLauri E Markowitz
Mar 28, 2012·Journal of Pain & Palliative Care Pharmacotherapy·UNKNOWN Centers for Disease Control and Prevention, Public Health Service, U.S. Department Health
Jul 4, 2013·BMC Infectious Diseases·Anneli UuskülaMatthew Pillsbury
Aug 7, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Wanrudee IsaranuwatchaiJeffrey S Hoch
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Margaret Stanley
Apr 29, 2015·Vaccine·Leslie WalwynNatalia Largaespada
Jun 14, 2015·The Lancet Oncology·Aimée R KreimerUNKNOWN GSK Vaccines Clinical Study Support Group
Jul 16, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·M SharmaJ J Kim
Aug 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ashish A DeshmukhScott B Cantor
Dec 22, 2015·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Katrin HaeusslerGianluca Baio
Apr 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·David P DurhamAlison P Galvani
Jun 16, 2016·Journal of Pain & Palliative Care Pharmacotherapy· Centers For Disease Control And Prevention Public Health Service U S Department Of Health And Human Services
Nov 9, 2016·BMC Infectious Diseases·Chrispin ChaguzaUNKNOWN PAGe Consortium
Dec 25, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allen LinMark Jit

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Citations

Aug 15, 2018·International Journal of Molecular Sciences·Ugo Moens
Jan 23, 2021·International Journal of Environmental Research and Public Health·Elizabeth McDermottHarri Weeks
Jul 28, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anne F RositchAaron A R Tobian
Oct 2, 2021·Experimental and Therapeutic Medicine·Arsenie Dan SpînuDan Liviu Dorel Mischianu

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