Should internal mammary lymph node sentinel biopsy be performed in breast cancer: a systematic review and meta-analysis

World Journal of Surgical Oncology
Jing GongXin Tu

Abstract

Results from studies of internal mammary lymph node sentinel biopsy are inconsistent. A comprehensive literature search was conducted in MEDLINE, EMBASE, Scopus, Cochrane database, and Clinical Trials. Studies reporting the rate of internal mammary lymph node sentinel biopsy (IMN-SLNB) positivity were identified. We performed pooled proportion meta-analysis using random-effects meta-analyses. The correlation of IMN and axillary lymph node (AXN) metastasis was also investigated. After application of inclusion and exclusion criteria, a total of 18 articles (total number of patients = 2427) were included. The pooled estimate for IMN-SLNB positivity rate was 15% (95% confidence interval (CI) 12-17%). Significant between-study heterogeneity was observed. Our results indicate that axillary lymph node metastasis is a strong predictor of IMN involvement (OR 6.01, 95% CI, 3.49, 10.34). Internal mammary lymph nodes metastasis might be underestimated. Patients with positive axillary lymph nodes have a higher risk of internal lymph nodes metastasis. As a result, IMN-SLNB might be considered in these patients. Future work needs to be done to assess whether pathological confirmed IMN metastasis can affect patients' survival.

References

Feb 5, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·U VeronesiR Zucali
May 3, 2000·Annals of Surgical Oncology·S L SuggR Heimann
Jun 23, 2000·International Journal of Radiation Oncology, Biology, Physics·B FowbleL Goldstein
Nov 6, 2002·Annals of Surgical Oncology·Viviana GalimbertiUmberto Veronesi
Oct 28, 2004·Clinical Breast Cancer·Robert E ManselUNKNOWN ALMANAC Trialists Group
Feb 18, 2006·Annals of Surgical Oncology·Marjut Hannele Kristiina LeideniusKarl Albert Johan von Smitten
May 10, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·U VeronesiR Orecchia
Aug 8, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E M HeutsA C Voogd
Aug 30, 2008·American Journal of Surgery·Eli AvisarFrederick L Moffat
Jan 15, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Jean-Cyril BourreJean-Philippe Vuillez
Jan 28, 2009·Surgical Oncology·Brian V HoganAbeer Shaaban
Jan 7, 2011·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Qingqing HeXueliang Li
Dec 17, 2011·International Journal of Radiation Oncology, Biology, Physics·Elif HindiéMarc Espié
Jun 1, 2012·International Journal of Surgical Pathology·Badr AbdullgaffarEliza Mohamed
Jun 9, 2012·Breast Cancer Research and Treatment·E L PostmaA J Witkamp
Oct 12, 2012·Oncology·Se Kyung LeeSeok Jin Nam
May 15, 2013·International Journal of Radiation Oncology, Biology, Physics·Christophe HennequinPascale Romestaing
Aug 13, 2013·Pathology Oncology Research : POR·R MarázG Cserni
Sep 21, 2013·Annals of Surgical Oncology·Jennifer L GnerlichDavid J Winchester
Sep 21, 2013·Annals of Surgical Oncology·Abigail S CaudleKelly K Hunt
Jun 15, 2015·Clinical Imaging·Kimberly M RayBonnie N Joe
Jul 23, 2015·The New England Journal of Medicine·Timothy J WhelanUNKNOWN MA.20 Study Investigators
Jul 23, 2015·The New England Journal of Medicine·Philip M PoortmansUNKNOWN EORTC Radiation Oncology and Breast Cancer Groups
Jul 27, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V OzmenM Dincer
Aug 19, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J Serrano-VicenteC Durán-Barquero
Apr 22, 2016·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·José Roberto Morales PiatoEdmund Chada Baracat

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Citations

Jun 24, 2021·World Journal of Surgical Oncology·Zhu-Jun LohHui-Ping Hsu

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Methods Mentioned

BETA
dissection
biopsy
imaging technique

Software Mentioned

STATA

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