Should living donor liver transplantation be an option when deceased donation is not?

Journal of Hepatology
Sarah R LieberRosamond Rhodes

Abstract

When a liver transplantation candidate is declined for listing to receive a deceased organ, sometimes a loved one comes forward and offers to be a living donor. This raises the ethical question of whether a patient who is not eligible for deceased donor liver transplantation should be eligible for living donor liver transplantation. We compare living organ donation in kidney and liver transplantation and explore key ethical concepts of justice, fairness, and societal trust. Ultimately, because there is no alternative life-preserving therapy in end-stage liver disease, and because transplantation with a living donor organ does not involve removing a resource from the common pool of transplant organs, we argue that a standard of "slightly less benefit" than that required for deceased transplantation should be used to determine the acceptability of living donor liver transplantation.

References

Feb 2, 2000·Langenbeck's Archives of Surgery·T Gutmann, W Land
Nov 21, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J F Renz, J P Roberts
Feb 28, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kimberly L BeaversRoshan Shrestha
Aug 30, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Andreas PascherPeter Neuhaus
Sep 28, 2004·Transplantation·UNKNOWN Ethics Committee of the Transplantation Society
Feb 25, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Philippa F MiddletonGuy Maddern
Nov 15, 2006·Clinical Transplantation·Jürgen WeitzJan Schmidt
Nov 15, 2006·Transplantation·Michael L VolkPeter A Ubel
Jun 28, 2007·Medicine, Health Care, and Philosophy·M E KnibbeM A Verkerk
Aug 19, 2007·Transplantation Proceedings·P Bruzzone, P B Berloco
Sep 12, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S PatelP Abt
Dec 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David C Cronin, J Michael Millis
Dec 23, 2008·Transplantation Proceedings·C B TanerJ H Nguyen
Jul 9, 2009·Transplantation·Yasuhiko HashikuraUNKNOWN Japanese Liver Transplantation Society
Dec 1, 2007·Hepatology International·Khalid AbdullahAbdulmajeed Abdulkareem
Jan 28, 2010·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Johan Friso LockMartin Stockmann
Mar 11, 2010·Transplantation·Taku IidaShinji Uemoto
Jun 11, 2010·Transplantation Proceedings·C Petrini
Jun 10, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Elizabeth A PomfretMark Siegler
Nov 4, 2011·The Lancet Oncology·Pierre-Alain ClavienUNKNOWN OLT for HCC Consensus Group
May 19, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E J Gordon
Jun 21, 2013·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Tiane JenningsDianne LaPointe Rudow
Sep 17, 2013·Transplantation Proceedings·N PanocchiaA G Spagnolo
Oct 30, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eric J KellerPaul R Helft
Dec 10, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kyung-Suk SuhKwang-Woong Lee
Feb 5, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas D SchianoRosamond Rhodes
May 25, 2015·Journal of Hepatology·Elisa J GordonTalia Baker
Apr 22, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jae Geun LeeMyoung Soo Kim
May 26, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G WongW H Lim
Dec 9, 2015·Clinical Liver Disease·Thomas D Schiano, Rosamond Rhodes

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Citations

Jan 23, 2020·Journal of Clinical Laboratory Analysis·Sergey GautierIrina Pashkova
Mar 28, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alexandra Shingina, Martin Montenovo
Jul 15, 2020·Expert Review of Gastroenterology & Hepatology·Michele FinottiUmberto Cillo
Feb 25, 2019·Irish Journal of Medical Science·Lubna Shazi, Zaigham Abbas
Nov 26, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Zaid HindiMayur Brahmania
Dec 19, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Stefano Di SandroFabrizio Di Benedetto
Feb 24, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas G CotterMichael Charlton
Aug 4, 2021·International Journal of Surgery Case Reports·Yoshikatsu SaitohTakashi Kamei

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