Should lung biopsies be performed in patients with severe asthma?

European Respiratory Review : an Official Journal of the European Respiratory Society
Daniel DobererSally E Wenzel

Abstract

Asthma, and severe asthma, in particular, is increasingly recognised as a heterogeneous disease. Identifying these different phenotypes of asthma and assigning patients to phenotype-specific treatments is one of the current conundrums in respiratory medicine. Any diagnostic procedure in severe asthma (or any disease) should have two aims: 1) better understanding or identifying the diagnosis, and 2) providing information on the heterogeneity of asthma phenotypes to guide therapy with the objective of improving outcomes. Lung biopsies can target the large and small airways as well as the lung parenchyma. All compartments are affected in severe asthma; however, knowledge on the distal lung is limited. At this point, it remains uncertain whether lung specimens routinely add diagnostic information that is unable to be obtained otherwise. Indeed, whether a lung biopsy is indicated in the workup of a patient with severe asthma remains an individual decision. It is hoped this review will support rational decision-making and provide a detailed synopsis of the varied histopathological features seen in biopsies of patients with a diagnosis of severe asthma. Due to limited data on this topic this review is primarily based on opinion with r...Continue Reading

References

Jun 8, 1978·The New England Journal of Medicine·M CosioP T Macklem
Mar 1, 1967·Journal of Applied Physiology·P T Macklem, J Mead
Jun 1, 1972·The Journal of Allergy and Clinical Immunology·P LiebermanR Kunske
Jun 4, 1970·The New England Journal of Medicine·G LevineP T Macklem
Jun 20, 1968·The New England Journal of Medicine·J C HoggW M Thurlbeck
Jun 1, 1969·The Journal of Clinical Investigation·A J WoolcockP T Macklem
Feb 1, 1993·The American Review of Respiratory Disease·N CarrollA James
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·M KraftR J Martin
Feb 1, 1997·The European Respiratory Journal·N CarrollA James
Feb 1, 1997·The European Respiratory Journal·J L FaulL W Poulter
Jul 1, 1997·The Journal of Allergy and Clinical Immunology·Q HamidJ C Hogg
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·S E WenzelR J Martin
Apr 3, 1998·The Journal of Allergy and Clinical Immunology·E M MinshallQ A Hamid
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·K J HaleyJ M Drazen
Dec 16, 1998·American Journal of Respiratory and Critical Care Medicine·H W ChuS E Wenzel
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·M KraftS T Holgate
Mar 9, 1999·The Journal of Allergy and Clinical Immunology·R A TahaQ A Hamid
Jul 7, 1999·Lancet·I D PavordA J Wardlaw
Aug 3, 2000·The New England Journal of Medicine·S SuissaB Cai
Nov 4, 2000·Respiratory Medicine·P K JefferyP Venge
Dec 9, 2000·American Journal of Respiratory and Critical Care Medicine·C OrdoñezJ V Fahy
Feb 17, 2001·American Journal of Respiratory and Critical Care Medicine·C L OrdoñezJ V Fahy
Apr 24, 2001·Archives of Disease in Childhood·D PayneA Bush
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·P K Jeffery
Feb 28, 2002·The European Respiratory Journal·V Giraud, N Roche
Sep 6, 2002·The European Respiratory Journal·S BalzarH W Chu
Oct 24, 2002·The European Respiratory Journal. Supplement·M Saetta, G Turato
Oct 31, 2002·American Journal of Respiratory and Critical Care Medicine·Patrick T Flood-PageDouglas S Robinson
Nov 21, 2002·Pharmacology & Therapeutics·Heike SchäckeKhusru Asadullah
Feb 7, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·H W ChuS E Wenzel
Jul 11, 2003·Chest·Henry A JenkinsJoseph D Spahn
Jul 18, 2003·The American Journal of Medicine·Laura M KuyperTony R Bai
Sep 17, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David A StevensUNKNOWN Participants in the Cystic Fibrosis Foundation Consensus Conference
Jan 10, 2004·The Journal of Allergy and Clinical Immunology·Christina MirandaSally E Wenzel
May 18, 2004·The American Journal of Medicine·Akio NiimiMichiaki Mishima
Jun 1, 2004·Inflammatory Bowel Diseases·R M Hoffmann, W Kruis

❮ Previous
Next ❯

Citations

Feb 3, 2016·Chest·Pauline PradereCamille Taillé
Jan 13, 2017·The American Journal of Surgical Pathology·Humberto E Trejo BittarSamuel A Yousem
Sep 24, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Morten HvidtfeldtCeleste Porsbjerg
Apr 19, 2019·Multidisciplinary Respiratory Medicine·Sara ColellaVenerino Poletti
Jan 10, 2019·Particle and Fibre Toxicology·Liza SelleyIan Mudway
Feb 24, 2020·Jornal de pediatria·Thiago Krieger Bento da SilvaBruno Hochhegger
Dec 17, 2020·American Journal of Respiratory and Critical Care Medicine·Sally E Wenzel
Jun 8, 2021·American Journal of Rhinology & Allergy·Jacqueline HoRichard J Harvey
Mar 13, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jacob A JeromeHumberto E Trejo Bittar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Annales pharmaceutiques françaises
A Rérat, Comité Scientifique OGM et Santé
Current Opinion in Pulmonary Medicine
Harold J Farber
Journal of Inherited Metabolic Disease
Joris FuijkschotMichèl A A P Willemsen
Current Opinion in Pediatrics
Daryl C OsbahrJeffrey R Dugas
© 2021 Meta ULC. All rights reserved