Should omega-3 fatty acids be used for adjuvant treatment of cancer cachexia?

Clinical Nutrition ESPEN
Daryna Sergiyivna LavrivPaula Ravasco

Abstract

Cancer cachexia is characterised by a progressive loss of muscle, resulting in functional impairment and shorter survival. Therefore, omega-3 has been studied for its role as an anti-cachectic therapy. This systematic review identified studies published on use of omega-3 in cancer cachexia in order to examine the potential benefit. A systematic review of the literature using PubMed and B-on databases was conducted to identify clinical trials published between 2000 and 2015, to evaluate the effect of n-3 PUFAs on nutritional features and Quality of Life in cancer cachexia. Of 140 publications, 7 were selected on the basis of their methodological quality, according to the Delphi List. The collected data was summarized and written in text format and in tables. Only one study, made in pre-cachectic population, show statistically and clinically positive intervention. No benefits were observed with the 4 g EPA/day, but a potentially clinically relevant treatment effect with 2 g EPA/day. Lung tumours showed the highest CRP levels and while the weight of patients with gastrointestinal cancer increased significantly, patients with lung cancer showed no significant response. Future cachexia trials would likely benefit from studying a sin...Continue Reading

Citations

Mar 17, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Matthew S BrookPhilip J Atherton
May 21, 2020·Nutrients·Jakub PobłockiMałgorzata Szczuko
May 1, 2019·Nutrients·Raquel D S Freitas, Maria M Campos
Aug 17, 2019·Journal of Clinical Medicine·Paula Ravasco
Dec 2, 2020·Cells·Giorgio AquilaRosanna Piccirillo
Jan 26, 2021·Clinical Nutrition ESPEN·Marília de Melo Freire LyraNassib Bezerra Bueno
Oct 23, 2020·Journal of Cachexia, Sarcopenia and Muscle·Pauline MorignyMaria Rohm
Jun 3, 2021·Nutrients·Alexandra PodpeskarChristina Salvador
Aug 25, 2021·Journal of Cachexia, Sarcopenia and Muscle·Pauline MorignyMauricio Berriel Diaz

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