Abstract
The relationship between diabetes mellitus and cancer of the pancreas is complex and incompletely understood. Nevertheless, it is generally agreed that new-onset diabetes in a patient over 50 Years old is a classical indication of pancreatic cancer. But there is no official directive in France that a scan should routinely be performed in such cases. We have studied 115 patients aged over 50 who were hospitalized for new-onset diabetes (fewer than 30 days) whose instability required insulin treatment. Routine imaging revealed abdominal disorders in 14 patients, 6 (5.2%) of whom were suffering from pancreatic adenocarcinomas. No clinical indication or laboratory test, apart from an unusually severe anorexia, suggested the discovered disorders. We therefore routinely carry out a pancreas scan, preferably by MRI, on all patients over 50 Years old presenting with new-onset diabetes, even if there are not clinical or laboratory indications of cancer. This is the only way in which small pancreatic cancers can be detected, thus providing the best hopes for successful treatment. Unfortunately, too often, this approach also detects only tumors that are already well developed. However, nowadays, it is not conceivable for a clinical team t...Continue Reading
References
Feb 13, 1992·The New England Journal of Medicine·A L Warshaw, C Fernández-del Castillo
Apr 1, 1989·Journal of Clinical Gastroenterology·J A RosaN N Abourizk
Mar 15, 1989·International Journal of Cancer. Journal International Du Cancer·J Cuzick, A G Babiker
May 1, 1988·Radiology·J P Campbell, S R Wilson
Jun 15, 1988·International Journal of Cancer. Journal International Du Cancer·R A HiattM A Armstrong
Nov 1, 1995·Radiology·D A BluemkeE K Fishman
Nov 1, 1994·British Journal of Cancer·C La VecchiaP Boyle
Jul 14, 1994·The New England Journal of Medicine·L GulloUNKNOWN Italian Pancreatic Cancer Study Group
Feb 3, 1994·The New England Journal of Medicine·J PermertT E Adrian
Jun 1, 1997·AJR. American Journal of Roentgenology·D S LuJ Sayre
Nov 14, 1997·Annals of Surgery·M TredeJ Schmoll
May 9, 1998·AJR. American Journal of Roentgenology·P LegmannA Bonnin
Sep 1, 1999·British Journal of Cancer·D T SilvermanJ F Fraumeni
Aug 2, 2001·Diabetes Technology & Therapeutics·H D StricklerH Yu
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·M K HerringtonJ Permert
Jan 1, 1833·Medico-chirurgical Transactions·R Bright
Citations
Mar 18, 2011·Pancreas·J Trent MagruderDana K Andersen
Jun 10, 2011·Pancreas·Phil A HartSuresh T Chari
Jul 14, 2012·Experimental Diabetes Research·Jan TrnaMarkéta Hermanová
Apr 22, 2014·PloS One·Brian M NolenAnna E Lokshin
Jul 29, 2010·Radiology·Jee Hyun BaekByung-Ihn Choi
Jul 8, 2014·Pancreas·Timothy B GardnerJ Marc Pipas
Jan 19, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Dóra IllésLászló Czakó
Aug 7, 2007·Seminars in Oncology·Suresh T Chari
Sep 11, 2012·Gastroenterology·Gaurav AggarwalSuresh T Chari
Nov 11, 2008·Annales d'endocrinologie·I SlimL Chaieb
Sep 28, 2007·The American Journal of Gastroenterology·Mario Pelaez-LunaSuresh T Chari
Sep 2, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Samir GuptaKenneth McQuaid
May 5, 2017·European Journal of Gastroenterology & Hepatology·Přemysl FričMiroslav Zavoral
Jun 11, 2009·The American Journal of Gastroenterology·Rahul PannalaSuresh T Chari
Jul 31, 2012·Endocrine-related Cancer·YunFeng Cui, Dana K Andersen
Nov 23, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Jemma Ahn, Jong Kyun Lee
Oct 17, 2018·Pancreas·Anirban MaitraUNKNOWN Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)
Feb 21, 2018·PloS One·Shu-Ta WuPinku Mukherjee
Aug 14, 2020·Diagnostics·Suguru MizunoKazuhiko Koike
Jan 24, 2007·Cancer Control : Journal of the Moffitt Cancer Center·Martine Extermann
Feb 16, 2021·Frontiers in Endocrinology·Shengjie WuLiping Chen
May 19, 2018·Gastroenterology·Ayush SharmaSuresh T Chari
Dec 7, 2007·Gastroenterology·Suresh T ChariGloria M Petersen
Dec 30, 2008·The Lancet Oncology·Rahul PannalaSuresh T Chari