Should patients with chronic hepatitis C infection be transplanted?

Transplantation Proceedings
R C Botero

Abstract

Chronic hepatitis C (HCV) infection affects more than 170 million people throughout the world and 2 to 3 million Americans. End-stage liver disease secondary to chronic HCV infection is the most frequent indication for liver transplantation in this country. Currently, the gold standard for treatment for immunocompetent patients is a combination of peginterferon (PEG-IFN) and ribavirin for 6 to 12 months depending on the genotype. This treatment achieves a sustained virological response (SVR) in 54% to 61% of patients overall. Almost 50% of patients do not respond or have recurrences posttreatment and progress in over 10 to 20 years into chronic liver disease and its complications. Liver transplantation is the only therapeutic modality that impacts on quality of life and survival of these patients. However, recurrence of HCV in the new allograft is universal with accelerated progression to cirrhosis in 5 to 10 years. Response to treatment is usually low (20% to 30%), and associated with significant side effects and depression. A significant percentage of patients with recurrent HCV after transplantation require retransplantation to control the complications of end-stage liver disease. Other solid organ transplants recipients alr...Continue Reading

References

Apr 10, 1975·The New England Journal of Medicine·S M FeinstoneP V Holland
Apr 1, 1992·The Journal of Clinical Investigation·C FérayC Bréchot
Apr 1, 1992·Kidney International·G Y MullerI V Machado
Sep 1, 1992·Scandinavian Journal of Gastroenterology·M YousufK Kiyosawa
Aug 15, 1991·The New England Journal of Medicine·B J PereiraA S Levey
Jan 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J J PoteruchaR H Wiesner
Feb 6, 1992·The New England Journal of Medicine·L Côté
Dec 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M Di BisceglieH J Alter
Apr 1, 1989·Kidney International·G D'AmicoR A Sinico
Dec 1, 1993·Journal of the American Society of Nephrology : JASN·D M Burstein, R A Rodby
Mar 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M BarreraA Ordinas
Feb 1, 1995·Seminars in Liver Disease·J BukhR H Purcell
Feb 1, 1995·Seminars in Liver Disease·N A Terrault, T L Wright
May 1, 1995·Kidney International·P Martin, L S Friedman
May 1, 1994·Kidney International·P KoenigK Gruenewald
Sep 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R DavdaJ Y Lau
Feb 15, 1996·Transplantation·P W LamL D Ferrell
Nov 27, 1996·Transplantation·V KliemU Frei
Jul 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G N DalekosK C Siamopoulos
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P MathurinM O Bitker
Dec 31, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E OkG Yüce
Jul 1, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J K DelladetsimaA Hatzakis
Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Mar 8, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G L ArmstrongH S Margolis
May 3, 2000·The Journal of Experimental Medicine·F LechnerB D Walker
May 29, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D ZdilarZ M Younossi
Aug 18, 2000·Seminars in Liver Disease·M Lechmann, T J Liang
Mar 23, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L Rostaing
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Montserrat Garcia-RetortilloJuan Rodes
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fabrizio FabriziPaul Martin
Jul 9, 2002·Clinical Transplantation·Marsha R HonakerA Osama Gaber

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Citations

Mar 25, 2014·World Journal of Gastroenterology : WJG·Massimiliano VerouxPierfrancesco Veroux
May 6, 2015·World Journal of Hepatology·Digdem Ozer EtikAhmet Sedat Boyacioglu
Jan 1, 2008·Substance Abuse : Research and Treatment·Thomas F KresinaH Westley Clark
Jul 2, 2009·The International Journal of Artificial Organs·Fabrizio FabriziPaul Martin

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