Should salvage surgery be considered for local recurrence after definitive chemoradiation in locally advanced non-small cell lung cancer?

Journal of Cardiothoracic Surgery
Waldemar SchreinerHoria Sirbu

Abstract

Incidence of local relapse after definitive chemoradiation (>59 Gy) for locally advanced non-small-cell lung cancer (NSCLC) is high, irrespective of high dose radiation applied. Experience with salvage lung resections in patients with locally relapsed NSCLC after definitive chemoradiation is limited. We present our series of salvage lung resections for local NSCLC relapse after curative-intent chemoradiation for locally advanced tumor. Nine consecutive patients with local tumor recurrence or persistence following definitive chemoradiation were reviewed. Kaplan-Meier analysis was used to assess patient survival. All patients received definitive radiation (median dose 66.2 Gy) with concurrent chemotherapy. Tumor stage prior to chemoradiation was IIIA in 8 patients and IV in 1. In 4 patients tumor invaded the chest wall, in 2 the spine and in 1 the aorta. Median interval between chemoradiation and salvage resection was 30.2 weeks. Nine patients underwent 9 resections (6 lobectomies, 1 bilobectomy, 1 pneumonectomy and 1 bi-segmentectomy). One death occurred on the 12th postoperative day. Median overall survival was 23 months; postoperative 3-year survival was 47 %. Median progression-free survival was 21 months. Salvage lung resect...Continue Reading

References

Apr 25, 2000·American Journal of Clinical Oncology·E L GressenW J Curran
Mar 2, 2002·International Journal of Radiation Oncology, Biology, Physics·Yoshiaki OkamotoYasumasa Kuroda
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nasser Hanna
Nov 17, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Marco TrovoJeffrey Bradley
Dec 4, 2009·Frontiers of Radiation Therapy and Oncology·Rainer Fietkau, Sabine Semrau
Mar 31, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anne AupérinJean-Pierre Pignon
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jeffrey Bradley
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Paul E Van Schil
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Fengshi ChenHiroshi Date
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shinya NeriMasaki Kokubo
Apr 15, 2011·International Journal of Radiation Oncology, Biology, Physics·Branislav Jeremić, Gregory M M Videtic
Apr 3, 2012·The European Respiratory Journal·Z AllibhaiA Bezjak
May 15, 2012·The Annals of Thoracic Surgery·Taichiro GotoHiroaki Nomori
Apr 6, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gregory A KuzmikAnthony W Kim
Mar 8, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hidetaka Uramoto, Fumihiro Tanaka
Apr 19, 2015·The Annals of Thoracic Surgery·Chi-Fu Jeffrey YangMark F Berry

❮ Previous
Next ❯

Citations

Mar 6, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Bing SunJoe Y Chang
Jan 24, 2018·Journal of Cardiothoracic Surgery·Erkan KabaAlper Toker
Jul 25, 2019·Surgical Case Reports·Masatoshi KanayamaFumihiro Tanaka

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
biopsy
surgical resection

Software Mentioned

SPSS

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.