PMID: 11309773Apr 20, 2001Paper

Should the cytologic diagnosis of "atypical squamous cells of undetermined significance" be qualified? An assessment including comparison between conventional and liquid-based technologies

Cancer
R C AntonD R Mody

Abstract

The diagnosis of atypical squamous cells of undetermined significance (ASCUS) remains an enigma for the treating physician, because it encompasses both benign, reactive, as well as preneoplastic and possibly neoplastic conditions. To address this problem, The Bethesda System recommends qualifying the ASCUS diagnosis. This study analyzes the difference in the follow-up results between the various groups of patients with an ASCUS diagnosis as outlined by the Criteria Committee: favor premalignant (ASCUS-P), favor reactive (ASCUS-R), and unqualified (ASCUS-C). The outcome, based on follow-up biopsies and/or cytologies, for both the conventional Papanicolaou smear (CS) and liquid-based (LB) methodologies is compared. The CS and LB biopsies and/or cytologies included 590 patients and 137 patients, respectively, who had an initial diagnosis of ASCUS. The final outcome after subsequent biopsy and cytology within a 1-year period for each methodology was tabulated. Furthermore, the addition of qualifiers for each diagnosis was tabulated for both cytology and biopsy follow-up and compared between CS and LB technologies. For CS, 29 patients (8.6%) were found to have squamous intraepithelial lesions (SIL) on subsequent cytologic smears, an...Continue Reading

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Citations

Oct 17, 2003·Clinics in Laboratory Medicine·Ritu Nayar, Sana O Tabbara
Nov 8, 2002·Cytopathology : Official Journal of the British Society for Clinical Cytology·J M EdwardsV F Hillier
Feb 24, 2005·Clinical Obstetrics and Gynecology·Barbara A Crothers
May 29, 2004·Cytopathology : Official Journal of the British Society for Clinical Cytology·D SchledermannB Hoelund

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