Should the use of contralateral prophylactic mastectomy be increasing as it is?

The Breast : Official Journal of the European Society of Mastology
William C Wood

Abstract

Recent studies have shown a dramatic increase in the use of contralateral prophylactic mastectomy (CPM). The choice of surgical procedure is primarily influenced by the recommendations of physicians and surgeons. As smaller breast cancers are detected by improved breast screening, and larger breast cancers are reduced in size by neo-adjuvant chemo- and endocrine therapy, breast conservation therapy (BCT) has been applicable to more women. No one would advocate CPM with the breast primary was to be treated by BCT. This makes the more than doubling of the rate of CPM even harder to understand. The ability to better define inherited breast cancer risk by genetic analysis of BRCA1 or 2 mutations does identify a group of patients at greatly increased lifetime risk of contralateral breast cancer (CBC). This segment of the population does not account for the sharp increase in CPM. It appears that many physicians and surgeons believe the risk of contralateral breast cancer to be sufficiently high to justify advising CPM. This risk is often overestimated by both healthcare providers and patients. The case for additional surgery should involve considerations of risk versus benefit, mortality being the principal patient concern and morbid...Continue Reading

References

Jan 14, 1999·The New England Journal of Medicine·L C HartmannR B Jenkins
Sep 24, 1999·Annals of Surgical Oncology·L L MontgomeryP I Borgen
Oct 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marlene H FrostLynn C Hartmann
Sep 7, 2006·Cancer·Judy C BougheyIsabelle Bedrosian

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Citations

Jun 4, 2013·The Lancet Oncology·John A MurphyJoseph M O'Donoghue
Feb 7, 2012·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·U GüthS M Schmid
Oct 10, 2012·ANZ Journal of Surgery·Toni MusielloChristobel Saunders
May 30, 2019·Breast Cancer Research and Treatment·Schelomo MarmorTodd M Tuttle
Nov 15, 2011·Familial Cancer·Pascal PujolUNKNOWN French Federation of Cancer Centres (FNCLCC)
Apr 16, 2016·Indian Journal of Surgical Oncology·Ismail Jatoi

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