Abstract
Bovine tuberculosis (bTB), caused by Mycobacterium bovis, is a serious infectious disease that remains an ongoing concern for cattle farming worldwide. Tuberculin skin-tests are often used to identify infected animals (reactors) during test-and-cull programs, however, due to relatively poor sensitivity, additional tests can be implemented in parallel. For example, in Northern Ireland interferon-gamma (IFN-g) testing is used in high-risk herds. However, skin-test negative animals which are positive to the IFN-g test are not required by law to be slaughtered - therefore the final choice for these animals' fate is left with the owner. During this study we investigated whether these animals represented a greater risk of becoming a skin reactor, relative to IFN-g test negative animals from the same herds. Our study population included 1107 IFN-g positive animals from 239 herds. A Cox-proportional hazard model indicated that animals which tested IFN-g positive were 2.31 times (95% CI: 1.92-2.79; P < 0.001) more likely to become a reactor compared with IFN-g negative animals. Animals from dairy herds, and from herds in the south-east, were of higher risk than animals from beef herds and other regions, respectively. Our findings sugges...Continue Reading
References
Sep 1, 1991·Australian Veterinary Journal·P R WoodN E Tweddle
Jul 21, 2001·Tuberculosis·J M PollockS D Neill
Sep 10, 2005·Veterinary Immunology and Immunopathology·J M PollockJ McNair
Dec 3, 2005·Veterinary Microbiology·E GormleyJ D Collins
Mar 4, 2006·Research in Veterinary Science·R de la Rua-DomenechR S Clifton-Hadley
Sep 2, 2006·The Veterinary Record·R GopalR Clifton-Hadley
Jun 6, 2009·Veterinary Research·Marie-France HumbletClaude Saegerman
Sep 15, 2009·Preventive Veterinary Medicine·Charles CaraguelLarry Hammell
Apr 20, 2010·Preventive Veterinary Medicine·A M Ramírez-VillaescusaL E Green
Jun 4, 2010·Proceedings. Biological Sciences·A R AllenS C Bishop
Apr 8, 2011·Veterinary Microbiology·Tracy A CleggSimon J More
May 7, 2011·Veterinary Medicine International·Margaret Good, Anthony Duignan
Jul 20, 2011·Preventive Veterinary Medicine·K KarolemeasJ L N Wood
Jan 1, 2009·Irish Veterinary Journal·G McGrathSj More
Aug 23, 2011·Preventive Veterinary Medicine·T A CleggS J More
Aug 27, 2011·The Veterinary Record·M GoodS J More
Jul 4, 2012·BMC Veterinary Research·Julio AlvarezLucas Domínguez
Aug 18, 2012·Preventive Veterinary Medicine·M C GatesM E J Woolhouse
Sep 12, 2012·Veterinary Medicine International·Robin A SkuceStanley W J McDowell
Oct 25, 2012·PLoS Computational Biology·Andrew J K ConlanJames L N Wood
Jan 1, 2013·Biostatistics·Candida GeerdensPaul Janssen
Jan 8, 2013·The Veterinary Record·D A AbernethyS J More
May 30, 2013·PloS One·Jan van Dijk
Jun 12, 2013·Preventive Veterinary Medicine·M J GallagherS J More
Nov 12, 2013·BMC Veterinary Research·M Carolyn GatesMark E J Woolhouse
Dec 7, 2013·Veterinary Research·Eamonn GormleyTracy A Clegg
Jan 15, 2014·BMC Veterinary Research·Julio ÁlvarezLucas Domínguez
Feb 11, 2014·The Veterinary Record
Apr 12, 2014·The Veterinary Record
Jul 16, 2014·Preventive Veterinary Medicine·L P DoyleK Stevens
Citations
Feb 21, 2016·Preventive Veterinary Medicine·T A CleggS J More
Apr 21, 2016·Preventive Veterinary Medicine·J A SinclairB M Buddle
Jul 31, 2016·Research in Veterinary Science·Angela Lahuerta-MarinAndrew W Byrne
Jan 25, 2018·Transboundary and Emerging Diseases·A W ByrneS W McDowell
Dec 30, 2017·BMC Veterinary Research·Andrew W ByrneStanley McDowell
Nov 24, 2018·The Veterinary Record·Rob Kelly
Sep 2, 2018·The Veterinary Record·Erik HoutsmaSimon J More
Nov 30, 2018·Transboundary and Emerging Diseases·Andrew W ByrneStanley W McDowell
Apr 16, 2016·Parasites & Vectors·Andrew W ByrneStanley W J McDowell
Jun 28, 2018·Parasitology Research·Andrew W ByrneMaria Guelbenzu-Gonzalo
Mar 15, 2018·Frontiers in Veterinary Science·Nicolas KeckStéphanie Desvaux
Mar 7, 2019·Frontiers in Veterinary Science·Andrew W ByrneSam Strain
Oct 16, 2018·Frontiers in Veterinary Science·Maria Luisa de la CruzJulio Alvarez
Jun 29, 2018·Frontiers in Veterinary Science·A R AllenA W Byrne
Mar 3, 2020·PeerJ·Georgina MilneAndrew W Byrne
Apr 8, 2017·The Veterinary Record·L McCallanA W Byrne
Dec 19, 2020·Frontiers in Veterinary Science·Alessandra MartuccielloEsterina De Carlo
May 24, 2017·Preventive Veterinary Medicine·A W ByrneS McDowell
Mar 5, 2019·Veterinary Microbiology·Michael CoadGareth Jones
Feb 12, 2019·Spatial and Spatio-temporal Epidemiology·G M MilneA W Byrne
Apr 14, 2021·PloS One·Lyanne McCallanAndrew W Byrne