Should We Care About Early Post-Stroke Rehabilitation? Not Yet, but Soon

Current Neurology and Neuroscience Reports
Steven R Zeiler

Abstract

Studies in humans and animal models show that most recovery from impairment occurs in the first 1-3 months after stroke as a result of both spontaneous recovery as well as increased responsiveness to enriched environments and training. Improvement from impairment is attributable to a short-lived "sensitive period" of post-stroke plasticity defined by unique genetic, physiological, and structural events. Unfortunately, rehabilitative interventions in humans have not been able to exploit this sensitive period similar to that seen in animal models. Here, we review these data and suggest a path forward. Pre-clinical data reveal underlying mechanisms that define the post-stroke sensitive period. These data are then discussed in the context of the spontaneous post-stroke recovery described in humans. Future work will need to capitalize on unique interactions between the sensitive period, spontaneous recovery, and novel types of rehabilitative interventions.

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Citations

Jan 14, 2020·Restorative Neurology and Neuroscience·Robert W RegenhardtDavid J Lin
Sep 17, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mustafa Balkaya, Sunghee Cho
Aug 11, 2020·PloS One·Jessica BarthAlexander W Dromerick
Oct 6, 2020·Neurorehabilitation and Neural Repair·Samar Hmaied AssadiDebbie Rand
May 7, 2021·Neurorehabilitation and Neural Repair·Scott R DeBoerSteven R Zeiler
Aug 28, 2021·Journal of Clinical Medicine·Ekaterina S KorolevaValentina M Alifirova
Aug 31, 2021·Neural Plasticity·Jinhuan ZhangHaibo Yu
Sep 22, 2021·Proceedings of the National Academy of Sciences of the United States of America·Alexander W DromerickDorothy F Edwards

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