Should We Monitor ScVO(2) in Critically Ill Patients?

Cardiology Research and Practice
Sophie Nebout, Romain Pirracchio


Hemodynamic monitoring has become a real challenge in the intensive care unit. As an integrative parameter for oxygen supply/demand, venous oxygen saturation (SvO(2)) provided by pulmonary artery catheterization is one of the most popular parameters to assess the adequacy of cardiac output. However, technical limitations and potential iatrogenic complications constitute important limits for a widespread use. Regular central venous catheters coupled with a fiberoptic lumen for central venous oxygen saturation (ScvO(2)) monitoring have been proposed as a surrogate for SvO(2) monitoring. The purpose of the present article is to review the physiological backgrounds of circulation, the pathophysiology of circulatory failure and subsequent venous oxygen saturation alterations, and finally the merits and the limits of the use of ScvO(2) in different clinical situations.


Jun 1, 1990·Clinical Science·C H KongF J Imms
Dec 1, 1990·The Journal of Trauma·T M ScaleaG W Shaftan
May 1, 1989·Critical Care Medicine·M O GayleT Brown
Apr 13, 1970·JAMA : the Journal of the American Medical Association·A M Hutter, A J Moss
Jan 1, 1984·Annales Françaises D'anesthèsie Et De Rèanimation·J J LehotJ Motin
Nov 1, 1982·Critical Care Medicine·J TahvanainenP Nikki
Dec 1, 1994·Journal of Applied Physiology·D M ManciniJ R Wilson
Feb 1, 1994·Journal of Applied Physiology·B ValletS M Cain
Jan 1, 1997·Critical Care Clinics·Z Feldman, C S Robertson
Apr 12, 2000·Acta Physiologica Scandinavica·R Boushel, C A Piantadosi
Jun 21, 2001·Respiration; International Review of Thoracic Diseases·C LadakisG Baltopoulos
Jan 17, 2002·The New England Journal of Medicine·E RiversEarly Goal-Directed Therapy Collaborative Group
Apr 12, 2003·Critical Care Medicine·Mitchell M LevySCCM/ESICM/ACCP/ATS/SIS
Jan 15, 2004·Intensive Care Medicine·Nicole NagdymanPeter E Lange
Jul 20, 2004·Intensive Care Medicine·Jean-Louis Vincent, Daniel De Backer
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Claudio Esteves LagoaMaurício Rocha e Silva
Dec 15, 2004·Chest·Lakhmir S ChawlaMuhammed Shah
Jun 2, 2005·Current Opinion in Critical Care·Konrad Reinhart, Frank Bloos
Dec 17, 2005·Critical Care : the Official Journal of the Critical Care Forum·Rupert PearseE David Bennett
Mar 25, 2006·Critical Care Medicine·Jean-Louis Vincent, Max Harry Weil
May 18, 2006·Critical Care : the Official Journal of the Critical Care Forum·Benjamin C H HoGeorge Braitberg
Aug 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·Paul W G Elbers, Can Ince
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·E NahumE D Skarsgard
Jan 12, 2007·The Journal of Trauma·Stephen M CohnStO2 in Trauma Patients Trial Investigators
Jun 19, 2007·Intensive Care Medicine·Jacques CreteurJean-Louis Vincent
Sep 22, 2007·Critical Care Medicine·Richard J Levy, Clifford S Deutschman
Dec 26, 2007·Critical Care Medicine·R Phillip DellingerWorld Federation of Societies of Intensive and Critical Care Medicine
Mar 6, 2008·Critical Care : the Official Journal of the Critical Care Forum·Paul A van BeestMichael A Kuiper
Oct 7, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Kwok M HoMax Bulsara
Jan 9, 2010·Critical Care : the Official Journal of the Critical Care Forum·Laurent HeyerDidier Payen
Dec 17, 2009·British Journal of Anaesthesia·J M Murkin, M Arango
Feb 25, 2010·JAMA : the Journal of the American Medical Association·Alan E JonesEmergency Medicine Shock Research Network (EMShockNet) Investigators
Nov 3, 2010·Critical Care : the Official Journal of the Critical Care Forum·Emmanuel FutierBenoit Vallet
May 26, 2011·The Journal of Trauma·Alejandro RodriguezJordi Rello


Oct 26, 2012·Anesthesiology Research and Practice·Jochen GilleArmin Sablotzki
Oct 4, 2018·BMJ Case Reports·Diana Elena Amariei, Robert Michael Reed
Jun 5, 2020·Journal of Intensive Care Medicine·Timothy W JonesAndrea Sikora Newsome
May 15, 2015·Emergency Medicine Journal : EMJ·Patrick A NeeKevin J Sim
Dec 15, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Oleksandr V OliynykWojciech Barg

Related Concepts

Critical Illness
Intensive Care Unit
Pulmonary Artery Catheterization
Structure of Lumen of Body System
Central Venous Catheter, Device
Monitoring - Action

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.