Should We Stop Saying 'Glia' and 'Neuroinflammation'?

Trends in Molecular Medicine
Roser MasgrauElena Galea

Abstract

Central nervous system (CNS) therapeutics based on the theoretical framework of neuroinflammation have only barely succeeded. We argue that a problem may be the wrong use of the term 'neuroinflammation' as a distinct nosological entity when, based on recent evidence, it may not explain CNS disease pathology. Indeed, the terms 'neuroinflammation' and 'glia' could be obsolete. First, unbiased molecular profiling of CNS cell populations and individual cells reveals striking phenotypic heterogeneity in health and disease. Second, astrocytes, microglia, oligodendrocytes, and NG2 cells may contribute to higher-brain functions by performing actions beyond housekeeping. We propose that CNS diseases be viewed as failed circuits caused in part by disease-specific dysfunction of cells traditionally called 'glia', and hence, favor therapies promoting their functional recovery.

Citations

Sep 19, 2017·Pediatric Research·Lauren L JantzieShenandoah Robinson
May 7, 2019·Glia·Ksenia V KastanenkaElena Galea
Sep 1, 2019·Current Alzheimer Research·Laura Trujillo-EstradaFrank M LaFerla
Nov 28, 2019·Molecular Psychiatry·Yun-Long TanLi Tian
May 8, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew D Gaudet, Laura K Fonken
Jan 16, 2019·Nature Reviews. Neuroscience·Christopher M HenstridgeTara L Spires-Jones
Jan 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Andrew G HortiMartin G Pomper
Feb 26, 2019·Frontiers in Neurology·Barry W Festoff, Bruce A Citron
Apr 6, 2018·Frontiers in Cellular Neuroscience·Stephen D SkaperPietro Giusti
Nov 12, 2019·Frontiers in Molecular Neuroscience·Thulani H PalpagamaAndrea Kwakowsky
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·Antonia Gutierrez, Javier Vitorica
Jun 1, 2018·Oxidative Medicine and Cellular Longevity·Kyoung Sang ChoSung Bae Lee
May 29, 2018·Journal of Neuroinflammation·Yiyi YangTomas Deierborg
Jun 13, 2018·Nature Medicine·Neibla PriegoManuel Valiente
Jul 26, 2018·Marine Drugs·Christian GalassoClementina Sansone
Jul 28, 2020·Cells·José A Rodríguez-GómezMiguel A Burguillos
Dec 18, 2020·Frontiers in Neurology·Paola PerinCinzia Boselli
Nov 1, 2020·Trends in Pharmacological Sciences·Lorenzo GaetaniLucilla Parnetti
Oct 15, 2020·International Journal of Molecular Sciences·Giovanna CasiliEmanuela Esposito
Mar 27, 2021·Mechanisms of Ageing and Development·Julie A Chowen, Luis M Garcia-Segura
Apr 24, 2021·Frontiers in Aging Neuroscience·Daniele LanaMaria Grazia Giovannini
Jun 18, 2021·Frontiers in Neurology·Agata MatejukHalina Offner
Aug 3, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Janani ManochkumarSiva Ramamoorthy
Oct 2, 2021·Clinical and Experimental Immunology·Luciano Stürmer de FragaVictorio Bambini-Junior
Dec 18, 2021·Journal of Medicinal Chemistry·Zohreh JafariPooyan Makvandi

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