Should women take part in clinical trials in breast cancer? Issues and some solutions

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
J CockburnA Kricker

Abstract

The purpose of this review is to consider the issues for women related to participation in clinical trials that evaluate the management of breast cancer and provide some recommendations for future initiatives to address the identified areas of concern. The National Health and Medical Research Council (NHMRC) National Breast Cancer Centre hosted an international workshop to address the question "Clinical Trials in Breast Cancer: Should Women Take Part?" We also reviewed the literature on informed participation in clinical trials that was identified in a broadly based search that covered Medline, PsycLIT, and HealthPlan from 1986 to 1996. When women are asked to participate in a clinical trial, they are faced with a number of questions and dilemmas. These include issues related to the conduct and ethical considerations of the trial; the effect of participation or nonparticipation on treatment; the roles of the doctor as clinician and as researcher; the process of informed consent; the timing of the request for participation; and the benefits and costs of participation. A number of steps are identified that could help women decide whether to participate in clinical trials. These include provision of community information about cli...Continue Reading

Citations

Jul 3, 1998·Journal of Women's Health·J Adams
Nov 5, 1999·Current Opinion in Oncology·A C Wolff
Jun 6, 2003·European Journal of Cancer Care·K Cox, J McGarry
Sep 17, 2002·Evaluation & the Health Professions·Davina Ghersi
Aug 17, 2002·Oncology Nursing Forum·Roseann Barrett

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