SHP-2 is involved in neurotrophin signaling

Biochemical and Biophysical Research Communications
N OkadaS Koizumi

Abstract

To investigate the involvement of SHP-2 in the signal transduction pathway stimulated by neurotrophins, the association of SHP-2 with components of the pathway was examined. Following NGF stimulation of PC12 cells, SHP-2 was found to be associated with the p85 subunit of PI3-kinase and the Shc proteins. In retinoic acid-differentiated SH-SY5Y cells and primary cultures of rat cortical neurons, BDNF treatment similarly caused the association of SHP-2 with p85. In addition, a tyrosine-phosphorylated protein, which is probably TrkB, was coimmunoprecipitated with SHP-2 in both cultures. These results show that SHP-2 becomes associated with signaling proteins after treatment with neurotrophins and suggest that SHP-2 plays a fundamental role in neurotrophin signaling.

Citations

Nov 29, 2011·Brain & Development·Yuahn-Sieh HuangKuo-Hsing Ma
Nov 15, 2007·Journal of Neurochemistry·Hiroaki MitsuhashiShoichi Ishiura
Dec 2, 1999·Experimental Cell Research·W J Friedman, L A Greene
May 27, 2014·Frontiers in Molecular Neuroscience·Rachel T Uren, Ann M Turnley
Aug 12, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Stoker, R Dutta
May 15, 2013·International Journal of Molecular Sciences·Vivek K GuptaStuart L Graham
Aug 8, 2007·Archives of Pharmacal Research·Hak-Jae KimYunhee Kim Kwon

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