Shrinkable Nanotubes for Duplex Formation of Short Nucleotides

Small
Naohiro Kameta, Haruhisa Akiyama

Abstract

Molecular monolayer nanotubes produced by self-assembly of an amphiphile modified with a 2-nitrobenzyl group as a photoresponsive unit are able to encapsulate dinucleotides via electrostatic attraction. Upon photoirradiation, the 18 nm inner diameter of the nanotubes shrinks to less than 2 nm as a result of photochemical cleavage of the 2-nitrobenzyl group in the amphiphile. This shrinking of the nanotube channels leads to a propulsive release of the dinucleotides into the bulk solution and simultaneously accelerates formation of the dinucleotide duplexes. The larger nanotube channels without photoirradiation merely release each dinucleotide into the bulk solution, indicating that the squeezing via transportation in the narrow nanotube channels is necessary for duplex formation. In addition to the size effect, water with a lower polarity confined within the narrow nanotube channels helps to stabilize the energetically unfavorable hydrogen-bonded base pair between the dinucleotides. This system should enable researchers to perform biological reactions that occur only in specific environments and conditions in living organisms.

References

Oct 22, 1955·Nature·F H CRICK, A RICH
Apr 14, 2005·Chemical Reviews·Toshimi ShimizuHiroyuki Minamikawa
Jul 22, 2006·Angewandte Chemie·Tao PengKazuhiko Nakatani
Feb 19, 2008·Journal of the American Chemical Society·Takahiro MuraokaSamuel I Stupp
Mar 12, 2008·Biochimie·Daisuke Miyoshi, Naoki Sugimoto
Jun 25, 2008·Annual Review of Biophysics·Huan-Xiang ZhouAllen P Minton
Nov 28, 2008·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Gerhard H FindeneggAndreas Schreiber
Jul 8, 2009·Angewandte Chemie·Takahiro MuraokaSamuel I Stupp
Dec 1, 2010·Chemical Communications : Chem Comm·Ryuhei NishiyabuJohn S Fossey
Apr 8, 2011·Chemistry : a European Journal·Naohiro KametaToshimi Shimizu
Feb 22, 2012·Science·T AidaS I Stupp
May 24, 2012·ACS Nano·Naohiro KametaToshimi Shimizu
Nov 15, 2012·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Akira YamaguchiNorio Teramae
Jul 19, 2013·Chemical Society Reviews·Xin WuYun-Bao Jiang
Jun 13, 2014·Angewandte Chemie·Ian W Hamley
Oct 14, 2014·Nature Communications·Hiroyuki ArafuneNorio Teramae
May 8, 2015·Chemistry : a European Journal·Naohiro KametaToshimi Shimizu
Oct 13, 2015·Nature Communications·Yongju KimMyongsoo Lee
Nov 28, 2015·Chemical Communications : Chem Comm·Naohiro KametaToshimi Shimizu
Apr 29, 2016·Chemistry : a European Journal·Naohiro KametaToshimi Shimizu
Jun 2, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Toshimi ShimizuMitsutoshi Masuda
Mar 28, 2017·Chemistry : a European Journal·Jian JiangMinghua Liu
Jan 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Naohiro KametaToshimi Shimizu
Mar 20, 2008·Soft Matter·Longliang WuAtsushi Maruyama

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.