Shuangshen Ningxin Capsule, a Traditional Chinese Medicinal Preparation, Alleviates Myocardial Ischemia through Autophagy Regulation

Evidence-based Complementary and Alternative Medicine : ECAM
Jun WangJian-xun Liu

Abstract

Shuangshen Ningxin capsule (SSNX), a modern Chinese formula, has been used to treat cardiovascular diseases in Eastern Asia. Our study focuses on the autophagy regulation of SSNX against coronary artery injuries. Myocardial infarction model was established in Chinese miniswines (CMS) by coronary artery balloon injury. SSNX was administered to the CMS for 8 weeks with 4 mg/kg or 16 mg/kg. Myocardial cells were incubated with 20% SSNX medicated serum for 2 hours. Assays were performed to detect the effects of SSNX on (i) coronary artery diameter by angiography, (ii) hemodynamics by noninvasive hemodynamic monitoring system, (iii) plaque burden and plaque volume by intravenous ultrasound (iv) coronary artery histology by H&E staining, (v) autophagosome by transmission electron microscopy, (vi) lactate dehydrogenase (LDH) leakage, and (vii) Beclin-1 and LC3-I/II expressions by Western blot. The results showed that CMS treated with SSNX exhibited the correction for the disturbed cardiac hemodynamics, increase of coronary artery diameter, reduction of high plaque burden and plaque volume, and decrease of LDH. The inhibitory effect of SSNX on CMS autophagy was demonstrated by the reduction of autophagosome and the downregulation of be...Continue Reading

References

Apr 1, 1996·Journal of Molecular and Cellular Cardiology·E GuardaP R Myers
Feb 1, 2000·Journal of Molecular and Cellular Cardiology·S YamamotoT N James
Jul 27, 2001·Cardiovascular Research·M W KnaapenM M Kockx
Sep 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lin YanStephen F Vatner
May 16, 2006·Journal of Molecular and Cellular Cardiology·Lauren ValentimAnastasis Stephanou
Aug 16, 2008·Heart·X-H ZhangL Liu
Mar 13, 2010·The Journal of Pathology·Danielle GlickKay F Macleod
Jun 9, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Suowen XuPeiqing Liu
Jul 3, 2013·Indian Heart Journal·Krishna Kumar SharmaRajeev Gupta
Aug 2, 2013·Antioxidants & Redox Signaling·Allen M AndresRoberta A Gottlieb
Jan 2, 2014·Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·Xue-Li LiYu-Jie Guo
Aug 19, 2014·Lancet·Daniel J Rader, G Kees Hovingh
Nov 5, 2014·Genetics and Molecular Research : GMR·S M YangC X Li

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
X-ray
coronary artery ligation
blood
light microscopy
Assay
electrophoresis
coronary artery angiographies

Software Mentioned

Volcano In - vision Gold Imaging System
IVUS
SPSS
Excel
QAngio XA

Related Concepts

Related Feeds

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Related Papers

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Xue-Li LiYu-Jie Guo
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Zhen YuXin-qing Feng
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
Jian-xun LiuXin-zhi Li
© 2021 Meta ULC. All rights reserved