Shunting inhibition, a silent step in visual cortical computation

Journal of Physiology, Paris
Yves FrégnacLyle Graham

Abstract

Brain computation, in the early visual system, is often considered as a hierarchical process in which features extracted in a given sensory relay are not present in previous stages of integration. In particular, orientation preference and its fine tuning selectivity are functional properties shared by most cortical cells and they are not observed at the preceding geniculate stage. A classical problem is identifying the mechanisms and circuitry underlying these computations. Several organizational principles have been proposed, giving different weights to the feedforward thalamocortical drive or to intracortical recurrent architectures. Within this context, an important issue is whether intracortical inhibition is fundamental for the genesis of stimulus selectivity, or rather normalizes spike response tuning with respect to other features such as stimulus strength or contrast, without influencing the selectivity bias and preference expressed in the excitatory input alone. We review here experimental observations concerning the presence or absence of inhibitory input evoked by non-preferred orientation/directions. Intracellular current clamp and voltage clamp recordings are analyzed in the light of new methods allowing us (1) to ...Continue Reading

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Citations

Jul 3, 2013·Pflügers Archiv : European journal of physiology·Hyun-Jong JangDuck-Joo Rhie
Sep 14, 2012·Neural Computation·Guy Ben-Yosef, Ohad Ben-Shahar
Nov 29, 2007·The American Journal of Forensic Medicine and Pathology·Joseph A Prahlow
Aug 5, 2008·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Guy Ben-Yosef, Ohad Ben-Shahar
Mar 31, 2005·Vision Research·Nicole D Anderson, Hugh R Wilson
Jan 20, 2015·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kayoung JooHyun-Jong Jang
Aug 27, 2010·Journal of Neurophysiology·Michael P Sceniak, Shasta L Sabo
Oct 31, 2020·SN Computer Science·Pablo BarrosAlessandra Sciutti

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