Shunting versus inactivation: simulation of GABAergic inhibition in spider mechanoreceptors suggests that either is sufficient

Neuroscience Research
Andrew S FrenchPäivi H Torkkeli

Abstract

Afferent neurons entering the central nervous systems of vertebrates and invertebrates receive presynaptic inhibition on their axon terminals. This usually involves an increase in membrane conductance (shunting) and depolarization (primary afferent depolarization, PAD). In arachnids and crustaceans the peripherally located parts of afferent neurons also receive efferent synapses. GABA (gamma-aminobutyric acid) plays a major role in both central and peripheral inhibition, activating chloride channels that depolarize the membrane and increase its conductance. Although both central and peripheral inhibition have been widely investigated, debate continues about the mechanisms involved, especially concerning the relative contributions of shunting versus inactivation of sodium channels by depolarization. Sensory neurons innervating spider VS-3 slit sensilla are accessible to intracellular recordings during mechanical or electrical stimulation. These neurons are inhibited by GABA, and both the electrophysiology and pharmacology of this inhibition have been studied previously. Here, we developed a Hodgkin-Huxley style model to simulate VS-3 neuron activity before and after GABA treatment. The model indicates that GABA-activated chlorid...Continue Reading

References

Feb 1, 1992·Trends in Neurosciences·P W Gage
Nov 1, 1996·Experimental Brain Research·F Clarac, D Cattaert
May 23, 1998·Annual Review of Pharmacology and Toxicology·R J Miller
Nov 7, 1999·Experimental Brain Research·P Rudomin, R F Schmidt
Aug 3, 2002·The European Journal of Neuroscience·Izabela PanekPäivi H Torkkeli
Sep 6, 2002·Microscopy Research and Technique·Päivi H Torkkeli, Izabela Panek
Dec 6, 2002·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Andrew S FrenchErnst-August Seyfarth
Jul 13, 2004·The European Journal of Neuroscience·Ewald GinglPäivi H Torkkeli
Feb 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexandre WidmerPäivi H Torkkeli
Mar 8, 2005·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Ulli Höger, Andrew S French
Aug 17, 2005·The European Journal of Neuroscience·Izabela Panek, Päivi H Torkkeli

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Citations

Oct 24, 2007·Annals of Biomedical Engineering·Andrew S French, Päivi H Torkkeli
Apr 4, 2008·Journal of Neurophysiology·Héctor I Rocha-GonzálezFrancisco J Alvarez-Leefmans
Sep 10, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mackenzie A Howard, Edwin W Rubel
Apr 8, 2011·Annual Review of Neuroscience·Gord Fishell, Bernardo Rudy
Oct 31, 2014·Nature Communications·Jeremy Tsung-chieh ChenJing Hu
Sep 27, 2014·Neuroscience·D Guo, J Hu
Nov 14, 2008·Journal of Neurophysiology·Keram PfeifferPäivi H Torkkeli
Jan 7, 2021·International Journal of Molecular Sciences·Antonella Comitato, Rita Bardoni
Sep 30, 2021·European Journal of Pain : EJP·Jorge Vicente-BazIvan Rivera-Arconada

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