Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan

Aging Cell
E G PasyukovaT F Mackay

Abstract

Variation in longevity in natural populations is attributable to the segregation of multiple interacting loci, whose effects are sensitive to the environment. Although there has been considerable recent progress towards understanding the environmental factors and genetic pathways that regulate lifespan, little is known about the genes causing naturally occurring variation in longevity. Previously, we used deficiency complementation mapping to map two closely linked quantitative trait loci (QTL) causing female-specific variation in longevity between the Oregon (Ore) and 2b strains of Drosophila melanogaster to 35B9-C3 and 35C3 on the second chromosome. The 35B9-C3 QTL encompasses a 50-kb region including four genes, for one of which, shuttle craft (stc), mutations have been generated. The 35C3 QTL localizes to a 200-kb interval with 15 genes, including three genes for which mutations exist (reduced (rd), guftagu (gft) and ms(2)35Ci). Here, we report quantitative complementation tests to mutations at these four positional candidate genes, and show that ms(2)35Ci and stc are novel candidate quantitative trait genes affecting variation in Drosophila longevity. Complementation tests with stc alleles reveal sex- and allele-specific f...Continue Reading

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Citations

Sep 1, 2005·Age·Luc Poirier, Laurent Seroude
Jun 8, 2006·Annual Review of Genomics and Human Genetics·Trudy F C Mackay, Robert R H Anholt
Apr 19, 2005·Genome Biology·Susan T HarbisonTrudy F C Mackay
Aug 6, 2010·PLoS Genetics·Michael M MagwireTrudy F C Mackay
Jun 20, 2006·Genetics·Katherine W JordanTrudy F C Mackay
Oct 11, 2013·Journal of Virology·Portia A Vliet-GreggRachel A Katzenellenbogen
Jul 22, 2009·Biochimica Et Biophysica Acta·Thomas Flatt, Paul S Schmidt
Oct 31, 2012·Evolution; International Journal of Organic Evolution·Silvia C RemolinaKimberly A Hughes
Jun 5, 2010·Plant Biology·C MüssigJ Lisso
Aug 22, 2006·Experimental Gerontology·Robert J Shmookler ReisSrinivas Ayyadevara
Jan 24, 2020·G3 : Genes - Genomes - Genetics·Grace A ParkerTrudy F C Mackay
Sep 18, 2015·PloS One·Megan Ulmer CarnesTrudy F C Mackay
Dec 20, 2018·Evolution Letters·Daniel K FabianThomas Flatt
Apr 4, 2021·Biology·Sreenivasulu Chintala, Rachel A Katzenellenbogen

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