PMID: 15351800Sep 8, 2004Paper

SIADH closely associated with non-functioning pituitary adenoma

Endocrine Journal
Masaru KandaSan-E Ishikawa

Abstract

We demonstrated severe hyponatremia in a 68 year-old man who had pituitary tumor. He had poor appetite and was disoriented. Tests revealed hyponatremia of 110 mmol/l, and he was admitted to Jichi Medical School Omiya Medical Center to undergo further tests. Physical findings revealed disturbance of consciousness with Japan Coma Scale I-2. There was neither dehydration nor edema. Laboratory data showed a serum sodium level of 112 mmol/l; plasma osmolality, 219 mmol/kg; and urinary osmolality, 555 mmol/kg. Plasma arginine vasopressin (AVP) level was 1.6 pmol/l despite the marked hypoosmolality. Anterior pituitary function was normal. Brain magnetic resonance imaging showed a pituitary tumor of 20 x 18 x 20 mm in size, which pushed the pituitary stalk upward. After the adenomectomy, serum sodium level was kept normal without any treatment. Histology showed basophilic adenoma. These findings indicate that local pituitary tumor may cause exaggerated secretion of AVP, resulting in the syndrome of inappropriate secretion of antidiuretic hormone (SIADH).

References

Feb 1, 1987·Annals of Internal Medicine·S E IshikawaT Kuzuya
May 1, 1974·Acta Endocrinologica·K C GreissD T Krieger
May 1, 1967·The American Journal of Medicine·F C Bartter, W B Schwartz

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Citations

Aug 12, 2006·Endocrine Journal·Takakazu KawamataTomokatsu Hori
May 29, 2007·Internal Medicine·Tomoyuki SaitoSan-e Ishikawa
Dec 19, 2007·Clinical Medicine & Research·Adedayo A OnitiloSuhail A R Doi
Oct 13, 2006·Journal of Endocrinological Investigation·A ZogheriA Peri
Aug 14, 2012·La Revue de médecine interne·T Frouget
Mar 20, 2010·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Lia NatteroMónica Marazuela
May 13, 2008·La Revue de médecine interne·B GranelY Frances
Aug 8, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Gal BordoDaniel F Kelly

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