Siah proteins: novel drug targets in the Ras and hypoxia pathways

Cancer Research
Colin M HouseDavid D L Bowtell

Abstract

The Siah (seven in absentia homolog) family of RING-domain proteins are components of ubiquitin ligase complexes, targeting proteins for proteasomal degradation. Siah family members have been reported to function in Ras, estrogen, DNA-damage, and hypoxia response pathways. Although earlier reports implicated Siah proteins as tumor suppressors, recent studies in mouse models have shown that Siah inhibition impairs tumor growth and metastasis. Given their central role in oncogenic and angiogenic pathways, Siah proteins are attractive novel therapeutic targets in cancer.

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·R W CarthewG M Rubin
Apr 5, 2000·The Journal of Biological Chemistry·J TanikawaS Ishii
Oct 18, 2000·The EMBO Journal·S J BoultonN Dyson
Dec 12, 2001·Nature Cell Biology·Thomas G HofmannM Lienhard Schmitz
Dec 14, 2001·Nature Structural Biology·Galina PolekhinaDavid D L Bowtell
Mar 9, 2002·Molecular and Cellular Biology·Ross A DickinsDavid D L Bowtell
May 23, 2002·Science·Ronald C ConawayJoan Weliky Conaway
Nov 2, 2002·The EMBO Journal·Hasem HabelhahZe'ev Ronai
Nov 6, 2002·Molecular and Cellular Biology·Ian J FrewDavid D L Bowtell
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Colin M HouseDavid D L Bowtell
Dec 3, 2003·Molecular and Cellular Biology·Ian J FrewDavid D L Bowtell
Oct 7, 2004·Oncogene·Chang Jae KimWon Sang Park
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jonna FrasorBenita S Katzenellenbogen
Apr 18, 2006·Structure·Colin M HouseGalina Polekhina
Aug 5, 2006·Journal of Cellular Biochemistry·Robert J NadeauRobert Friesel
May 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Scott AlperDavid A Schwartz
Jun 10, 2008·Nature Cell Biology·Melanie WinterThomas G Hofmann
Jul 17, 2008·Breast Cancer Research and Treatment·Maurice P H M JansenEls M J J Berns
Oct 14, 2008·Oncogene·A MöllerD D L Bowtell
Oct 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jianfei QiZe'ev Ronai
Nov 13, 2008·Journal of the National Cancer Institute·Atique U AhmedAmy H Tang
Dec 2, 2008·Nature Cell Biology·Marco A CalzadoM Lienhard Schmitz
Jan 31, 2009·Nature Reviews. Cancer·Adam Telerman, Robert Amson
Apr 18, 2009·Molecular Cancer Research : MCR·Koh NakayamaZe'ev Ronai

❮ Previous
Next ❯

Citations

Mar 9, 2012·Molecular Genetics and Genomics : MGG·Michelle E CasadHoward A Rockman
Nov 23, 2010·Breast Cancer Research and Treatment·Kathryn C BehlingAgnieszka K Witkiewicz
Feb 12, 2013·Medical Oncology·Xue-Kui LiuMu-Sheng Zeng
Oct 6, 2012·Leukemia·O H KrämerS K Knauer
Aug 11, 2012·Journal of Molecular Cell Biology·Moisés PérezMarco A Calzado
Dec 10, 2013·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Vadim RimsaWilliam N Hunter
Jun 3, 2011·Journal of Virology·Claus-Henning NagelJoachim Hauber
May 9, 2014·PLoS Genetics·Marzia ScortegagnaZe'ev A Ronai
Oct 25, 2013·International Journal of Biological Sciences·Kuppusamy Balamurugan, Esta Sterneck
Nov 6, 2012·Clinical Lung Cancer·Niki KarachaliouRafael Rosell
Jan 12, 2016·Oncogene·C García-LimonesM A Calzado
Aug 16, 2015·Microvascular Research·Christina S F WongAndreas Möller
May 1, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·James N MusyokaIan A Darby
Jan 15, 2014·International Journal of Cancer. Journal International Du Cancer·Jie YinXi-Zhong Shen
May 9, 2012·Current Opinion in Neurobiology·David J Solecki
Jun 26, 2015·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Devika Srivastava, Oishee Chakrabarti
Jul 31, 2013·Chemistry & Biology·John L StebbinsMaurizio Pellecchia
Nov 1, 2011·The International Journal of Biochemistry & Cell Biology·Kristin PietschmannOliver H Krämer
Mar 19, 2013·Biochemical and Biophysical Research Communications·Kelly VelascoKristina Lindsten
Sep 10, 2014·PloS One·Anupriya GopalsamyKunchithapadam Swaminathan
Oct 25, 2016·Biochimica Et Biophysica Acta. General Subjects·Qi ZhangYufeng Tong
Oct 30, 2015·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ya GaoXiuwei Chen
Aug 9, 2017·BMC Evolutionary Biology·Ian J PepperAmy H Tang
Dec 28, 2018·Veterinary World·Ferbian Milas SiswantoBambang Hadi Kartiko
Aug 11, 2020·World Journal of Gastroenterology : WJG·Sinem Cil GonulcuGulsum Ozlem Elpek
Dec 22, 2014·Oncotarget·Anna ChenAndreas Möller
May 17, 2014·Oncotarget·Sylvia MüllerOliver H Krämer
Jan 21, 2011·Cancer Research·Johanna CroneThomas G Hofmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.