Sialic acid catabolism and transport gene clusters are lineage specific in Vibrio vulnificus.

Applied and Environmental Microbiology
Jean-Bernard LubinE Fidelma Boyd

Abstract

Sialic or nonulosonic acids are nine-carbon alpha ketosugars that are present in all vertebrate mucous membranes. Among bacteria, the ability to catabolize sialic acid as a carbon source is present mainly in pathogenic and commensal species of animals. Previously, it was shown that several Vibrio species carry homologues of the genes required for sialic acid transport and catabolism, which are genetically linked. In Vibrio cholerae on chromosome I, these genes are carried on the Vibrio pathogenicity island-2 region, which is confined to pathogenic isolates. We found that among the three sequenced Vibrio vulnificus clinical strains, these genes are present on chromosome II and are not associated with a pathogenicity island. To determine whether the sialic acid transport (SAT) and catabolism (SAC) region is universally present within V. vulnificus, we examined 67 natural isolates whose phylogenetic relationships are known. We found that the region was present predominantly among lineage I of V. vulnificus, which is comprised mainly of clinical isolates. We demonstrate that the isolates that contain this region can catabolize sialic acid as a sole carbon source. Two putative transporters are genetically linked to the region in V. ...Continue Reading

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Citations

Dec 24, 2015·International Journal of Environmental Research and Public Health·Nadja BierEckhard Strauch
Jan 22, 2015·Letters in Applied Microbiology·N BierE Strauch
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Sep 10, 2015·Microbiology Spectrum·Brandy L Haines-MengesE Fidelma Boyd
Nov 7, 2015·Microbiology Spectrum·E Fidelma BoydW Brian Whitaker
Oct 2, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mario López-PérezSalvador Almagro-Moreno

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