Sialic acid content in serum IgG from patients with myotonic dystrophy compared with healthy controls

Acta Neurologica Scandinavica
O Sydow

Abstract

One of the determinants of the lifetime of circulating glycoproteins is their content of the terminal carbohydrate sialic acid. In order to elucidate a possible mechanism behind reduced concentration of IgG in patients with myotonic dystrophy, serum IgG was isolated by affinity chromatography and its content of sialic acid determined. No difference between patients and healthy controls was found. The results provide further support to the idea that a host factor rather than an abnormality of the IgG molecule itself is responsible for the low concentration of serum IgG in this disease.

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Citations

Jan 31, 2007·BMC Neurology·Susan SparksWilliam A Gahl
Jul 20, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mustafa CemekFatma Yilmaz
Aug 31, 2018·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Halim UlugolFevzi Toraman

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