Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition.

FEBS Letters
Biswajit KhatuaChitra Mandal

Abstract

The opportunism of Pseudomonas aeruginosa (PA) in immunocompromised hosts prompted us to explore the potential role of sialic acids (Sia) in this phenomenon. Culture of PA in the presence of exogenous Sia resulted in linkage-specific incorporation of Sia which was associated with decreased complement deposition on the bacteria. Sia acquired by PA mediated enhanced binding of bacteria to recombinant-CHO cells expressing human siglec-7 or siglec-9, as well as to human NK-cells and monocytes naturally expressing these siglecs. Therefore, Sia may be acquired by PA in the host and contribute to bacterial pathogenicity and host-cell interactions via reduction of complement deposition and siglec-dependent recognition.

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Citations

May 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ajit Varki
Aug 10, 2011·Infection and Immunity·Ferric C Fang, Arturo Casadevall
Jul 6, 2014·Glycobiology·Yung-Chi Chang, Victor Nizet
Oct 22, 2013·Expert Review of Respiratory Medicine·Vignesh VenkatakrishnanMorten Thaysen-Andersen
Mar 26, 2016·Frontiers in Oncology·Ana Flávia Fernandes Ribas NardyAlexandre Morrot
Apr 25, 2012·Annals of the New York Academy of Sciences·Ajit Varki, Pascal Gagneux
Feb 1, 2012·Annals of the New York Academy of Sciences·James C PaulsonNorihito Kawasaki
Jul 16, 2014·Biochimica Et Biophysica Acta·Christian BüllGosse J Adema
Jan 13, 2015·Journal of Autoimmunity·Emanual MaverakisCarlito B Lebrilla
Jul 19, 2013·Virulence·Uthaman Gowthaman, Veraragavan P Eswarakumar
Feb 24, 2015·Frontiers in Immunology·Alex Langford-SmithSimon J Clark
Apr 20, 2017·Chembiochem : a European Journal of Chemical Biology·Jonathan Okerblom, Ajit Varki
Mar 20, 2014·Molecular & Cellular Proteomics : MCP·Biswajit KhatuaChitra Mandal
Jan 3, 2013·European Journal of Immunology·Munir Akkaya, A Neil Barclay
Apr 10, 2020·Frontiers in Immunology·Valarmathy MurugaiahUday Kishore
Oct 28, 2019·Nature Communications·Pedro BuleGideon J Davies
Dec 13, 2016·Cellular and Molecular Life Sciences : CMLS·Raffaella ParenteAnthony J Day
May 7, 2019·The Journal of Infectious Diseases·Youssif M AliMona I Shaaban
Feb 13, 2021·Cells·Philip Rosenstock, Thomas Kaufmann
Jun 1, 2021·Frontiers in Cellular and Infection Microbiology·Tainá CavalcanteBeatriz Simonsen Stolf

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Methods Mentioned

BETA
flow cytometry
ELISA

Software Mentioned

Master Totallab

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