Sialic acids: biomarkers in endocrinal cancers

Glycoconjugate Journal
Shyamasree Ghosh

Abstract

Sialylations are post translational modification of proteins and lipids that play important role in recognition, signaling, immunological response and cell-cell interaction. Improper sialylations due to altered sialyl transferases, sialidases, gene structure and expression, sialic acid metabolism however lead to diseases and thus sialic acids form an important biomarker in disease. In the endocrinal biology such improper sialylations including altered expression of sialylated moieties have been shown to be associated with disorders. Cancer still remains to be the major cause of global death and the cancer of the endocrine organs suffer from the dearth of appropriate markers for disease prediction at the early stage and monitoring. This review is aimed at evaluating the role of sialic acids as markers in endocrinal disorders with special reference to cancer of the endocrine organs. The current study is summarized under the following headings of altered sialylations in endocrinal cancer of the (i) ovary (ii) pancreas (iii) thyroid (iv) adrenal and (v) pituitary gland. Studies in expression of sialic acid in testis cancer are limited. The future scope of this review remains in the targeting of endocrinal cancer by targeting altere...Continue Reading

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Citations

Sep 30, 2016·Medicinal Research Reviews·Rémi Szabo, Danielle Skropeta
Jun 27, 2017·Polymers·Yuting XiongTaolei Sun
Jul 31, 2018·Glycoconjugate Journal·Shyamasree Ghosh
Oct 6, 2017·ACS Chemical Neuroscience·Lucas VeillonYehia Mechref
Apr 4, 2020·Journal of the American Chemical Society·Yuting XiongGuangyan Qing

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