PMID: 2101800Jan 1, 1990Paper

Sialidase activity in rimantadine-resistant and -sensitive influenza A viruses

Enzyme
A García-SastreJ A Cabezas

Abstract

Rimantadine-resistant and -sensitive influenza A variants were assayed for their sialidase (neuraminidase, EC 3.2.1.18) activity. The kinetic parameters determined (pH optimum, stability against different pH values, thermal stability, activity on methylumbelliferyl-alpha-D-N-acetylneuraminic acid, N-acetylneuraminyl-lactose, fetuin and bovine submandibular gland mucin as substrates, Km with the former substrate, inhibition by two competitive inhibitors, and behavior towards amantadine) revealed the same results for both variants of the virus. Thus, it can be deduced that resistance to rimantadine does not influence the sialidase activity of influenza A virus.

Citations

Feb 17, 2000·The Journal of General Virology·A SolorzanoA García-Sastre

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