Sialochemical and oxidative analyses in radioactive I131-treated patients with thyroid carcinoma

European Journal of Endocrinology
Sophia Ish-ShalomRafael M Nagler

Abstract

I131 in relatively high doses has been shown in the past to cause damaging salivary effects and oral discomfort in patients. Although lower dosage is now widely accepted, I131 may still be the source of salivary damage over the long-term and subsequent harmful effects on both the oral cavity and the gastrointestinal tract, into which the saliva is swallowed. This study examined the effects of radioactive I131 on salivary gland activity, saliva composition and oxidative profile, and related oral discomfort complaints following thyroidectomy due to carcinoma of thyroid gland. Out of 40 consenting female post-thyroidectomy patients, 23 (mean age 50+/-4 years old) were treated with I131 while 17 (mean age 46+/-4) were not. Whole saliva from all subjects was analyzed for antioxidant and biochemical composition and flow rate. The salivary flow rates of both groups were similar but their composition differed considerably. Salivary superoxide dismutase enzyme (SOD), total protein, and albumin concentrations were significantly reduced in the treated patients by 40, 25, and 18% respectively (P<0.05), as were all other salivary antioxidants. Oral discomfort complaints were far more prevalent in the I131-treated patients. I131-dependent da...Continue Reading

Citations

Apr 24, 2013·Thyroid : Official Journal of the American Thyroid Association·Jeong-Seok ChoiYoung-Mo Kim
Oct 18, 2011·Endocrine-related Cancer·Dong WangYu-Wei Yang
Aug 2, 2013·Future Oncology·Zohreh Noaparast, Seyed Jalal Hosseinimehr
Mar 20, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·S B JensenUNKNOWN Salivary Gland Hypofunction/Xerostomia Section, Oral Care Study Group, Multinational Association of Supportive Care in Cance
Jul 3, 2015·Thyroid : Official Journal of the American Thyroid Association·Gi Hyeon SeoSun Wook Kim
Dec 30, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Chuan-Bin WuLiang-Mei Zhang
Dec 31, 2019·Clinical Hemorheology and Microcirculation·Tarik SengozMelek Bor-Kucukatay
Mar 20, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bin LiuRong Tian

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