Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition

Cell
Mark R CharbonneauJeffrey I Gordon

Abstract

Identifying interventions that more effectively promote healthy growth of children with undernutrition is a pressing global health goal. Analysis of human milk oligosaccharides (HMOs) from 6-month-postpartum mothers in two Malawian birth cohorts revealed that sialylated HMOs are significantly less abundant in those with severely stunted infants. To explore this association, we colonized young germ-free mice with a consortium of bacterial strains cultured from the fecal microbiota of a 6-month-old stunted Malawian infant and fed recipient animals a prototypic Malawian diet with or without purified sialylated bovine milk oligosaccharides (S-BMO). S-BMO produced a microbiota-dependent augmentation of lean body mass gain, changed bone morphology, and altered liver, muscle, and brain metabolism in ways indicative of a greater ability to utilize nutrients for anabolism. These effects were also documented in gnotobiotic piglets using the same consortium and Malawian diet. These preclinical models indicate a causal, microbiota-dependent relationship between S-BMO and growth promotion.

References

Jan 1, 1987·Annual Review of Nutrition·E R Miller, D E Ullrey

❮ Previous
Next ❯

Citations

Jan 12, 2017·Nature Reviews. Gastroenterology & Hepatology·Wendy S Garrett
Mar 9, 2017·Cell Metabolism·Niv ZmoraEran Elinav
Feb 17, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Tyler VaivadaZulfiqar A Bhutta
Apr 5, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Galia Gat-YablonskiMoshe Phillip
Dec 8, 2017·Calcified Tissue International·Martin SchwarzerFrançois Leulier
Aug 22, 2017·Calcified Tissue International·René Rizzoli, Emmanuel Biver
Oct 21, 2017·Nutrition Reviews·Stephan ThurlBernd Stahl
Nov 28, 2017·Nucleic Acids Research·Na L GaoWei-Hua Chen
Aug 30, 2017·Cold Spring Harbor Perspectives in Medicine·Roberto Pacifici
Feb 13, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Martin Schwarzer
Oct 12, 2017·Calcified Tissue International·Emory Hsu, Roberto Pacifici
Feb 6, 2018·Annual Review of Immunology·Andrew J MacphersonStephanie C Ganal-Vonarburg
Feb 28, 2018·Frontiers in Immunology·Olaf PerdijkR J Joost van Neerven
Nov 20, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Preeyam Patel, John F Kearney
Jan 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eran BlacherEran Elinav
Dec 9, 2017·Future Microbiology·Edward Pk ParkerNicholas C Grassly
Dec 17, 2017·Science Immunology·Kathryn A KnoopRodney D Newberry
Aug 5, 2017·Clinical Microbiology Reviews·Marwa K IbrahimPeter C Melby
Apr 28, 2018·Circulation Research·Robert W McGarrahChristopher B Newgard
Dec 5, 2018·Canadian Journal of Physiology and Pharmacology·Mark A UnderwoodRobin H Steinhorn
Oct 31, 2018·Nature Medicine·Aimee M Baumann-DudenhoefferGautam Dantas
Nov 9, 2018·Molecular Nutrition & Food Research·Richard You WuPhilip M Sherman
Jan 18, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hongbin LiuShiyan Qiao
Feb 28, 2019·Microbiome·UNKNOWN 2017 NIH-wide microbiome workshop writing team
Mar 1, 2019·Molecular Biology of the Cell·Alex C Broussard, Michael Boyce
Dec 8, 2017·The Biochemical Journal·Francesca BottaciniMarco Ventura
Aug 29, 2017·Critical Reviews in Food Science and Nutrition·Daotong LiFang Chen
Oct 7, 2016·Nature Medicine·Bjoern O Schroeder, Fredrik Bäckhed
Mar 1, 2016·Nature Reviews. Microbiology·Andrea Du Toit

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.