Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

Organic & Biomolecular Chemistry
Kelly M CraftSteven D Townsend

Abstract

Human milk oligosaccharides (HMOs) possess antimicrobial activity against a number of bacterial pathogens. HMOs prevent infection by serving as decoy receptors that competitively bind pathogens thus preventing pathogen attachment to host epithelial cell receptors. In a second mechanistic pathway, we recently demonstrated that heterogenous HMO extracts exert antimicrobial action against Group B Streptococcus by increasing cellular permeability. As human milk contains ca. 200 unique glycans however, our understanding of which pharmacophores are most important to HMO antimicrobial activity remains immature. In the present study, we describe the first evaluation of the antimicrobial and antibiofilm activities of five structurally defined, ubiquitous sialylated HMOs against Group B Streptococcus.

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Citations

Apr 16, 2019·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Steven D Townsend
May 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Birgitte ZeunerAnne S Meyer
Sep 12, 2019·Open Biology·Rebecca E Moore, Steven D Townsend
Apr 23, 2020·Nutrients·Magdalena Orczyk-Pawiłowicz, Jolanta Lis-Kuberka
Jun 21, 2020·Nutrients·Mostafa AsadpoorSaskia Braber
May 28, 2020·Frontiers in Immunology·Marit ZuurveldLinette E M Willemsen
Feb 24, 2019·The Journal of Antibiotics·Kelly M Craft, Steven D Townsend
Aug 10, 2020·Nature Communications·Matthew J AmicucciCarlito B Lebrilla
Jul 1, 2020·Biochemical Society Transactions·Schuyler A Chambers, Steven D Townsend
Jan 21, 2021·ACS Infectious Diseases·Rebecca E MooreSteven D Townsend
Jul 24, 2021·Journal of the American Chemical Society·Lianyan L Xu, Steven D Townsend
Feb 15, 2019·Accounts of Chemical Research·Kelly M Craft, Steven D Townsend
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Marefa JahanBing Wang
Sep 29, 2021·Chembiochem : a European Journal of Chemical Biology·Rebecca E MooreJennifer A Gaddy

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