Siatic nerve regeneration in rats stimulated by fibrin glue containing nerve growth factor: an experimental study

Injury
Chunzheng GaoJianmin Li

Abstract

To study the effects of fibrin sealant containing nerve growth factor on the peripheral nerve regeneration. A four-group experimental design with repeated measures on one factor was used. Fibrin glue (FG) containing NGF was injected into the site of end-and-end sutured peripheral nerve (sciatic nerve) (group I: NGF+FG), meanwhile three control groups were set-up: group II (NGF), group III (FG), and group IV (normal saline). Observation to the function and morphology of the sciatic nerve was carried out at the end of 4, 8, 12 weeks postoperation. Data were analyzed using ANOVA, with the appropriate post hoc between-groups comparison test. Electrophysiological testing. The NAP and NCV of group I (NGF+FG) were greater than those of group II (NGF), group III (FG), or group IV (normal saline) (p<0.05). Sciatic functional index (SFI). It began to ameliorate at 4 weeks postoperation and SFI increased as time went on. And the SFI in group I (NGF+FG) was better than those in group II (NGF), group III (FG), or group IV (normal saline) (p<0.05). Morphology. In the MGF-stained sections, dissociated myelin debris was less and regenerated nerve fibres were in larger quantities in group I (NGF+FG) than in other groups. In the HE-stained secti...Continue Reading

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Citations

Dec 3, 2013·The Journal of Surgical Research·Emile RijckenPhilipp-Alexander Neumann
Aug 25, 2009·Journal of Tissue Engineering and Regenerative Medicine·Vineet AgrawalStephen F Badylak
Oct 16, 2015·Journal of Orthopaedic Surgery and Research·Bilal GümüsOsman Arslan Bora
May 5, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Xiaowen JiangWenhui Yu
Jul 20, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Patrick P Spicer, Antonios G Mikos
May 6, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Elahe MasaeliLorenzo Moroni
Apr 27, 2012·Acta Cirúrgica Brasileira·Daniel Nunes e SilvaDiogo Gomes Augusto
Jun 13, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·E Carlos Rodriguez-Merchan
Sep 11, 2019·Chinese Journal of Integrative Medicine·Chun-Hong ZhangMin-Hui Li
Aug 12, 2021·Journal of Korean Neurosurgical Society·Gokhan GurkanOytun Erbas

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