Sibling rivalry among paralogs promotes evolution of the human brain.

Cell
Chris Tyler-Smith, Yali Xue

Abstract

Geneticists have long sought to identify the genetic changes that made us human, but pinpointing the functionally relevant changes has been challenging. Two papers in this issue suggest that partial duplication of SRGAP2, producing an incomplete protein that antagonizes the original, contributed to human brain evolution.

References

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Citations

Sep 19, 2012·Biochimie·Steve Meaney
May 6, 2015·Reproduction, Fertility, and Development·Xiang LinYong Zhang
Nov 11, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mukta Chakraborty, Erich D Jarvis

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