Sibship characteristics during upbringing and schizophrenia risk

American Journal of Epidemiology
C B Pedersen, P B Mortensen

Abstract

The potential association between sibship characteristics and the risk of schizophrenia has been investigated previously. However, methods have differed and results have been conflicting. The authors explored the association between birth order, sibship size, and birth interval to siblings and schizophrenia while accounting for potential confounders. Using Danish Civil Registration System data, the authors established a cohort of 763,000 people. Schizophrenia was identified by linkage with the Danish Psychiatric Central Register. Overall, 2,536 people developed schizophrenia from 1986 to 2001. Children with no siblings and children with three or more siblings had significantly increased risks (relative risk = 1.22 and 1.27, respectively). This association was explained by change of residence and urbanization during upbringing. Children with half siblings had a significantly increased risk (relative risk = 1.20). The authors found a significantly increased risk associated with siblings 7-8 and 11-14 years younger (relative risk = 1.30 and 1.22, respectively) combined with a significantly decreased risk associated with siblings 2-10 and 12 or more years older (relative risk = 0.92 and 0.82, respectively). There was no consistent ...Continue Reading

Citations

Jun 15, 2011·Social Psychiatry and Psychiatric Epidemiology·Daniel Vincent RiordanCameron Stark
Dec 14, 2012·Schizophrenia Bulletin·Philip Rising NielsenEsben Agerbo
Jun 8, 2006·The Australian and New Zealand Journal of Psychiatry·Thomas StompeHans Schanda
Jan 21, 2006·BMC Psychiatry·Carsten Bøcker Pedersen, Preben Bo Mortensen
Jun 27, 2013·Child Psychiatry and Human Development·Leena StenuddKaisa Riala
Feb 15, 2013·Social Psychiatry and Psychiatric Epidemiology·Juan J CarballoEnrique Baca-García
Jul 17, 2007·Schizophrenia Research·Janice A HustedAnne S Bassett
May 16, 2006·Bipolar Disorders·Carsten Bøcker Pedersen, Preben Bo Mortensen
Nov 22, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Elizabeth Cantor-Graae, Carsten Bøcker Pedersen
Aug 26, 2015·Molecular Psychiatry·A K MerikangasE A Heron
May 6, 2006·American Journal of Epidemiology·Carsten B Pedersen, Preben Bo Mortensen

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