Sibutramine administration decreases serum anti-Müllerian hormone (AMH) levels in women with polycystic ovary syndrome

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Christos VosnakisD Panidis

Abstract

To investigate the effect of diet, physical exercise and sibutramine administration on serum anti-Müllerian hormone (AMH) levels, hormonal and metabolic parameters in overweight and obese patients with polycystic ovary syndrome (PCOS). Prospective clinical study, in an outpatient clinic setting, of 76 overweight and obese women with PCOS. All patients were placed on a hypocaloric diet, physical exercise plus sibutramine (10 mg per day) for the first month and then on either a hypocaloric diet, physical exercise plus sibutramine (10 mg per day) or a hypocaloric diet and physical exercise for the subsequent 6 months. Serum AMH levels, body composition, hormonal and metabolic features and insulin sensitivity indices were evaluated at baseline and at 4 and 7 months of treatment. Body weight reduction was greater in the sibutramine group. Moreover, serum FSH and testosterone levels decreased, and SHBG, free androgen index and all indices of insulin resistance significantly improved at 4 and 7 months. Serum AMH levels decreased only in PCOS women who received sibutramine, at both 4 and 7 months of treatment. A hypocaloric diet and a diet plus sibutramine both resulted in significant weight loss in overweight and obese women with PCOS...Continue Reading

References

Sep 1, 1991·The Journal of Clinical Endocrinology and Metabolism·S M PloskerR B Jaffe
Jan 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J E NestlerW G Blackard
Sep 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J P DeslypereA Vermeulen
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·A MayerhoferS R Ojeda
Feb 28, 2002·Endocrinology·Alexandra L L DurlingerAxel P N Themmen
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·L J MoranR J Norman
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Apr 28, 2004·Neurotoxicity Research·T NakagawaH Okamura
Dec 22, 2005·The Journal of Clinical Endocrinology and Metabolism·P PignyD Dewailly
Jan 3, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Jenny A VisserAxel P N Themmen
Dec 12, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D FlorakisD Panidis
Feb 25, 2009·PloS One·Mona R El-TalatiniJustin C Konje
Nov 21, 2009·Journal of Pharmacological Sciences·Ana Cristina MartínezSara Benedito
Sep 15, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dimitrios PanidisEvanthia Diamanti-Kandarakis

❮ Previous
Next ❯

Citations

Feb 27, 2018·Human Reproduction·E Nilsson-CondoriB Friberg
Feb 23, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Fan ZhangXiao-Wen Huang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Related Papers

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Christos VosnakisD Panidis
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
D PanidisE Diamanti-Kandarakis
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
Li-Na Jia, Xing-Juan Wang
© 2021 Meta ULC. All rights reserved