Sibutramine reduces feeding, body fat and improves insulin resistance in dietary-obese male Wistar rats independently of hypothalamic neuropeptide Y

British Journal of Pharmacology
M BrownJ Wilding

Abstract

We studied the effects of the novel noradrenaline and serotonin (5-HT) reuptake inhibitor sibutramine on feeding and body weight in a rat model of dietary obesity, and whether it interacts with hypothalamic neuropeptide Y (NPY) neurones. Chow-fed and dietary-obese (DIO) male Wistar rats were given sibutramine (3 mg kg(-1) day(-1) p.o.) or deionized water for 21 days. Sibutramine decreased food intake throughout the treatment period in both dietary-obese rats (P<0.0001) and lean rats (P<0.0001). Weight gain was reduced so that final body weight was 10% lower in dietary-obese (P<0.005) and 8% lower in lean (P<0.05) rats versus their untreated controls. Plasma leptin concentration was lower in sibutramine-treated dietary-obese rats (P<0.05), and in treated lean rats (P<0.05). Using the homeostasis model assessment (HOMA) as a measure of insulin resistance, untreated DIO rats were significantly more insulin resistant than controls (P<0.005), and this was corrected by sibutramine treatment (P<0.05). Neither hypothalamic NPY mRNA nor NPY peptide levels in a number of hypothalamic nuclei were significantly altered by sibutramine compared to untreated controls. The hypophagic and anti-obesity effects of sibutramine in dietary-obese Wis...Continue Reading

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Citations

Jun 23, 2011·Reviews in Endocrine & Metabolic Disorders·Stephanie Sisley, Darleen Sandoval
Nov 26, 2003·Physiology & Behavior·M LeBlanc, L Thibault
May 19, 2007·Digestive Diseases and Sciences·Junying Xu, Jiande Dz Chen
Oct 24, 2007·Pharmacology & Therapeutics·John D Fernstrom, Sujean Choi
Nov 13, 2004·Obesity Research·Basil KünneckeMarkus von Kienlin
Jun 20, 2006·British Journal of Pharmacology·Angels FisasPetrus Johan Pauwels
Feb 9, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·T J Atkinson
Jan 27, 2006·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D R Powell
Oct 1, 2015·Metabolic Brain Disease·Magdalena DudekMarcin Kołaczkowski
Aug 18, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Niels VrangPhilip Just Larsen

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