Sicca symptoms are associated with similar fatigue, anxiety, depression, and quality-of-life impairments in patients with and without primary Sjögren's syndrome

Joint, Bone, Spine : Revue Du Rhumatisme
Morgane MilinValérie Devauchelle-Pensec

Abstract

To compare quality of life (QoL), depression, anxiety, and fatigue in prospectively included patients with primary Sjögren's syndrome (pSS) or with sicca but no diagnosis of Sjögren's syndrome. Patients undergoing a multidisciplinary evaluation at a single university center in Brest, France, for suspected pSS and having sicca symptoms were included prospectively between November 2006 and December 2013. The same standardized investigations were performed in all patients. pSS and sicca not due to pSS diagnoses were based on evaluating physician opinion. Each patient completed three validated questionnaires on QoL (SF-36), fatigue (MFI), depression and anxiety (HADS). Of the 95 included patients, 55 (57.9%) had pSS and 40 (42.1%) had sicca without pSS. Gender distribution, age, disease duration, and sicca symptoms were similar in the two groups. The pSS group had a significantly higher proportion of patients with abnormal objective tests for dryness (Schirmer's test and salivary flow rate). The SF-36, HADS, and MFI scores were similarly altered in the two groups. Anxiety was more common than depression in both groups. The most affected domains were vitality in the SF-36 and general/physical fatigue in the MFI. Extraglandular syste...Continue Reading

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Citations

Mar 3, 2017·Joint, Bone, Spine : Revue Du Rhumatisme·Pierre GazeauValérie Devauchelle-Pensec
Jun 18, 2017·Psychology, Health & Medicine·Yafei CuiBiyu Shen
Feb 17, 2019·Rheumatology·Samira T MiyamotoBenjamin A Fisher
Jul 15, 2016·Nature Reviews. Rheumatology·Alain SarauxValérie Devauchelle-Pensec
Nov 4, 2017·British Dental Journal·R Ní Ríordáin, P Wiriyakijja
Nov 2, 2019·Annals of the Rheumatic Diseases·Manuel Ramos-CasalsUNKNOWN EULAR-Sjögren Syndrome Task Force Group
Jul 23, 2016·Journal of Neuroscience Research·Katherine A Mifflin, Bradley J Kerr
May 6, 2017·Clinical Reviews in Allergy & Immunology·Guillermo Carvajal AlegriaDivi Y K Cornec
Dec 14, 2018·International Journal of Molecular Sciences·Fabíola Reis de OliveiraEduardo Melani Rocha
Dec 11, 2019·Rheumatology·Guillermo Carvajal Alegria, Divi Cornec
Apr 29, 2020·Rheumatology·Guillermo Carvajal Alegria, Divi Cornec

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