Sickle cell anaemia trial

Statistics in Medicine
M H Gaston, J I Verter

Abstract

The major cause of death in sickle cell anaemia is from infection, especially infection caused by Streptococcus pneumoniae. Meningitis, pneumonia and septicaemia caused by this organism are the primary types of infection leading to death. Children under three years of age are at highest risk. We have known for over twenty years that approximately 30 per cent of the infants born with sickle cell anaemia will become infected in the first three years of life and one-third can be expected to die from the infection. These data were the reason that we conducted the Prophylactic Penicillin Study (PROPS), a trial to investigate the effectiveness of oral prophylactic penicillin in preventing severe infection due to S. pneumoniae. This investigation was a very efficient, cost effective study because of its timeliness and its conduct within the framework of an ongoing study. Moreover, the question being answered was simple and focused with up-to-date data that permitted accurate estimates of sample size and incidence.

Associated Clinical Trials

References

Jul 1, 1977·American Journal of Diseases of Children·G D OverturfL J Baraff
Jun 19, 1986·The New England Journal of Medicine·M H GastonJ S Lobel
Jan 1, 1972·American Journal of Diseases of Children·R A SeelerM A Mufson
Jan 19, 1970·JAMA : the Journal of the American Medical Association·S A Kabins, C Lerner
May 5, 1966·The New England Journal of Medicine·M G Robinson, R J Watson
May 8, 1981·JAMA : the Journal of the American Medical Association·D PowarsL Chan

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Citations

Mar 4, 2008·The Journal of Sexual Medicine·Nelson Bennett, John Mulhall
Jan 16, 2015·Journal of Applied Oral Science : Revista FOB·Fernanda Lourenção BrighentiCristiane Yumi Koga-Ito
Oct 11, 2017·The Cochrane Database of Systematic Reviews·Angela E Rankine-Mullings, Shirley Owusu-Ofori
Mar 17, 2021·The Cochrane Database of Systematic Reviews·Angela E Rankine-Mullings, Shirley Owusu-Ofori

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