Sickle cell anemia and fetal hemoglobin

The American Journal of the Medical Sciences
M H Steinberg

Abstract

Fetal hemoglobin, the predominant hemoglobin of the fetus, is good for sickle cell anemia. This hemoglobin inhibits the polymerization of sickle hemoglobin. Clinical studies have shown that at any level of fetal hemoglobin, the more that is present, the better off is the patient. We are now able to increase fetal hemoglobin levels by pharmacologic means. We should know shortly if this is associated with clinical benefit.

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·Y W Kan, A M Dozy
Jan 1, 1992·Journal of Cell Science. Supplement·M MinieG Felsenfeld
Jul 10, 1992·Cell·A Bird
Apr 1, 1992·Baillière's Clinical Haematology·R L Nagel, A F Fleming
Apr 12, 1990·The New England Journal of Medicine·G P RodgersA W Nienhuis
Jul 4, 1991·The New England Journal of Medicine·O S PlattT R Kinney
Apr 19, 1991·Science·G Stamatoyannopoulos
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N MonplaisirJ Rosa
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J DeSimoneD Zwiers
Jun 1, 1983·American Journal of Hematology·M H Steinberg, R P Hebbel
Aug 1, 1984·The Journal of Clinical Investigation·O S PlattD G Nathan
Jan 14, 1993·The New England Journal of Medicine·G P RodgersA W Nienhuis
Jun 9, 1994·The New England Journal of Medicine·O S PlattP P Klug

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Citations

Dec 20, 2011·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·N RuffieuxR Sztajzel
Mar 3, 2018·International Journal of Molecular Sciences·Rosario Di MaggioAurelio Maggio
Apr 8, 1999·Anaesthesia·A J Vipond, L D Caldicott

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