Sickle cell disease and nitric oxide: a paradigm shift?

The International Journal of Biochemistry & Cell Biology
A Kyle Mack, Gregory J Kato

Abstract

Traditionally the pathophysiology of sickle cell disease is thought to result from the polymerization of hemoglobin S in red cells, under hypoxic conditions, resulting in the occlusion of blood vessels. Adhesion of cells to the venular endothelium also appears to play a role. Recent studies have also suggested that in addition to the polymerization of hemoglobin S in the red blood cell, a deficiency of the endogenous vasodilator, nitric oxide may be involved. Hemoglobin released as a result of hemolysis rapidly consumes nitric oxide resulting in a whole program of events that inhibit blood flow. Therapies directed at decreasing the destruction of nitric oxide, increasing the production of nitric oxide, or amplifying the nitric oxide response may prove beneficial.

References

Dec 1, 1990·The American Journal of the Medical Sciences·C O EnwonwuE Turner
Jul 21, 1998·The Journal of Biological Chemistry·X LiuJ R Lancaster
Jun 23, 2000·Annals of the New York Academy of Sciences·M AslanB A Freeman
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·M AslanB A Freeman
Nov 12, 2002·Nature Medicine·Christopher D ReiterMark T Gladwin
Jan 23, 2003·Circulation·Mark T GladwinRichard O Cannon
Mar 8, 2003·JAMA : the Journal of the American Medical Association·Debra L WeinerCarlo Brugnara
Apr 4, 2003·JAMA : the Journal of the American Medical Association·Martin H SteinbergMichael Terrin
Aug 7, 2003·Journal of Pediatric Hematology/oncology·Claudia R MorrisFrans A Kuypers
Sep 26, 2003·American Journal of Hematology·Robert T EberhardtJoseph A Vita
Nov 5, 2003·Nature Medicine·Kenyatta CosbyMark T Gladwin
Feb 27, 2004·The New England Journal of Medicine·Mark T GladwinFrederick P Ognibene
Jun 11, 2004·The New England Journal of Medicine·Elizabeth S Klings, Harrison W Farber
Aug 12, 2004·Free Radical Biology & Medicine·S Bruce King
Sep 1, 2004·Histochemistry and Cell Biology·Barbara VoetschJoseph Loscalzo
Sep 14, 2004·Nature Medicine·Christian J HunterMark T Gladwin
Jan 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hunter C ChampionArthur L Burnett
Apr 7, 2005·JAMA : the Journal of the American Medical Association·Russell P RotherMark T Gladwin
Apr 20, 2005·The Journal of Biological Chemistry·Kris T HuangNeil Hogg
Jun 1, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katherine C WoodD Neil Granger
Jun 30, 2005·Blood·Vikki G NolanMartin H Steinberg
Jul 7, 2005·JAMA : the Journal of the American Medical Association·Claudia R MorrisMark T Gladwin
Jul 26, 2005·The Journal of Clinical Investigation·Zhi HuangMark T Gladwin
Jul 27, 2005·British Journal of Haematology·Roberto F MachadoMark T Gladwin
Sep 28, 2005·The Journal of Biological Chemistry·Ivan AzarovDaniel B Kim-Shapiro
Nov 18, 2005·Methods in Enzymology·T Scott IsbellRakesh P Patel
Nov 19, 2005·The Journal of Clinical Investigation·Peter C MinneciSteven B Solomon

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Citations

Oct 4, 2013·Journal of Human Genetics·Sudhansu Sekhar NishankAnil Gwal
Apr 22, 2009·Blood·Marianne Jensby Nielsen, Søren Kragh Moestrup
Oct 11, 2012·Revista brasileira de hematologia e hemoterapia·Romélia Pinheiro Gonçalves
Oct 11, 2012·Revista brasileira de hematologia e hemoterapia·Darcielle Bruna Dias EliasRomélia Pinheiro Gonçalves
Sep 20, 2006·Pharmacogenomics·Alexandros C MakisJustin Stebbing
Dec 12, 2012·Biomarkers in Medicine·Talyta Ellen de Jesus Dos SantosRomélia Pinheiro Gonçalves
Jun 16, 2012·Anemia·Elisabeth H JavazonDavid R Archer
Jun 26, 2010·The Journal of Emergency Medicine·Alexander L RogovikRan D Goldman
Jul 8, 2009·Clinical Biochemistry·Nicola Conran, Fernando F Costa
Jun 3, 2008·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·J-P Cartron, J Elion
Sep 9, 2015·Basic & Clinical Pharmacology & Toxicology·Maritza Cavalcante BarbosaRomélia Pinheiro Gonçalves Lemes
Feb 17, 2009·Medicinal Research Reviews·Ernst E van FaassenMark T Gladwin
Oct 6, 2007·British Journal of Haematology·R Ward HagarClaudia R Morris
Oct 19, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Anazoeze Jude MaduChukwudi Anigbo
Sep 16, 2011·Journal of Clinical Laboratory Analysis·Romélia Pinheiro GonçalvesJacqueline Holanda de Souza
Sep 18, 2010·European Journal of Haematology·Iryna RusanovaDario Acuña-Castroviejo
May 28, 2011·European Journal of Clinical Investigation·Ino KanavakiIoannis Papassotiriou
Apr 20, 2011·Journal of Clinical Pharmacy and Therapeutics·A A AbushamI S Al-Zakwani
Sep 28, 2010·American Journal of Hematology·Caterina P MinnitiSamir K Ballas
Sep 27, 2015·Revista brasileira de hematologia e hemoterapia·Bruna Spinella Pierrot-GalloMaria Stella Figueiredo
Jul 1, 2015·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Melinda D WuJonathan R Lindner
Dec 4, 2014·Blood Cells, Molecules & Diseases·Nara GaviniManjit Hanspal
Sep 27, 2016·International Journal of Dermatology·Hojjat AfradiShahram Teimourian
Oct 6, 2016·Pediatric Research·Emily Riehm Meier, Angeli Rampersad
Oct 28, 2016·Expert Review of Medical Devices·Yunus AlapanUmut A Gurkan
Mar 25, 2017·Blood Cells, Molecules & Diseases·Berenike MöckeschSophie Antoine-Jonville
May 16, 2014·The International Journal of Lower Extremity Wounds·Simone C O GilliSara T Olalla Saad
Dec 9, 2014·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalMaria José Martinez-Zapata
Jan 11, 2018·Lung India : Official Organ of Indian Chest Society·Abhinav AgrawalArunabh Talwar
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Arturo J Martí-CarvajalArturo J Martí-Peña
Oct 21, 2006·Current Opinion in Hematology·Claudia R MorrisMark C Walters
Oct 6, 2007·American Journal of Hematology·Paola SebastianiMartin H Steinberg
Feb 12, 2009·Hemoglobin·Nicola ConranFernando F Costa
Oct 1, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gwen LagodaArthur L Burnett
Oct 8, 2019·The Cochrane Database of Systematic Reviews·Arturo J Martí-Carvajal, Luis H Agreda-Pérez
Jan 28, 2020·Experimental Biology and Medicine·Alina Sadaf, Charles T Quinn

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