Abstract
In order to define the morbidity profile of sickle cell disease in Omani children, we analysed data on 97 children (53 boys, 44 girls) aged < or = 12 years admitted under our care in a regional referral hospital between July 1999 and June 2000. Ninety of them had sickle cell anaemia (HbSS disease) and seven had sickle cell thalassaemia (beta zero). Their mean (SD) steady-state Hb was 7.9 (1.2), range 6-10 g/dl. They were admitted on 316 occasions during the 12-month period. The number of admissions per child ranged from one to 12 (mean 3.3). Vaso-occlusive crises were the main reason for admission (83%), followed by severe anaemia (12%) and infections (4%). During the study period, 31% received blood transfusions. Weight faltering was very common, 68% falling below the 5th percentile of the National Center for Health Statistics reference curves compared with 28% of age- and sex-matched non-sicklers (p < 0.001). Other complications included hypersplenism (four), ischaemic necrosis of the femoral head (two), and one case each of acute chest syndrome, acute splenic sequestration, cholelithiasis and pathological fracture of a lumbar vertebra. Overall, 71% of the children had moderately severe or severe disease. This pattern seems t...Continue Reading
References
Mar 1, 1979·The American Journal of Clinical Nutrition·P V HamillW M Moore
Jan 1, 1978·Annals of Internal Medicine·R P PerrineF Shoup
Jul 4, 1991·The New England Journal of Medicine·O S PlattT R Kinney
Sep 1, 1991·British Journal of Haematology·M A PadmosG R Serjeant
Jan 1, 1991·Annals of Tropical Paediatrics·N BashirL Sharif
Aug 1, 1990·Journal of Tropical Pediatrics·M A el-HazmiA S Warsy
Jan 1, 1989·Annals of the New York Academy of Sciences·O O Akinyanju
Aug 1, 1985·Journal of Medical Genetics·M A BuhazzaF P Khouri
Apr 1, 1983·Journal of Tropical Pediatrics·W N Kaine
Jan 1, 1980·Transactions of the Royal Society of Tropical Medicine and Hygiene·A S Ibrahim
Jul 1, 1994·British Journal of Haematology·G R SerjeantP W Thomas
Jan 1, 1996·British Journal of Haematology·G SerjeantP Thomas
Jun 1, 1996·Pediatric Clinics of North America·P A Lane
Jan 1, 1996·Acta Haematologica·A D Adekile, M Z Haider
Oct 1, 1996·American Journal of Hematology·M S FigueiredoF F Costa
Oct 1, 1996·Community Dentistry and Oral Epidemiology·M Al-IsmailyM Knight
Oct 1, 1996·The Journal of Obstetrics and Gynaecology Research·K TalafihS Jaradat
Mar 1, 1995·Current Opinion in Hematology·G R Serjeant
Apr 1, 1999·The New England Journal of Medicine·M H Steinberg
May 8, 1992·Current Opinion in Ophthalmology·A D Penman, G R Serjeant
May 20, 1999·Archives of Disease in Childhood·S A MagnusG R Serjeant
Aug 7, 1999·Acta Haematologica·R MouéléF Galactéros
Feb 24, 2000·Archives of Disease in Childhood·P W ThomasG R Serjeant
Jul 20, 2000·Annals of Hematology·S A Kaaba, L Al Fazaa
Sep 28, 2000·European Journal of Haematology·M G NeonatoR Girot
Citations
Aug 28, 2012·TheScientificWorldJournal·Samir K BallasPunam Malik
Aug 30, 2008·Annals of Tropical Paediatrics·A-W M Al-SaqladiB J Brabin
Dec 2, 2010·Annals of Tropical Paediatrics·A-W M Al-SaqladiB J Brabin
Apr 20, 2014·BMC Public Health·Omar A Al-FarsiSamir Al-Adawi
Sep 6, 2012·European Journal of Pediatrics·Carmen GarridoJorge Huerta
Sep 17, 2004·Ophthalmic Epidemiology·Rajiv KhandekarJawad Al Lawati
Aug 25, 2007·Annals of Tropical Paediatrics·Olufemi Jaiyesimi, Mohamed Kasem
Apr 24, 2008·Bone·Ellen B FungUNKNOWN Multi-Center Iron Overload Study Group
May 20, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·C Garrido ColinoE Cela de Julián
Nov 21, 2015·Anemia·Zeina A Salman, Meaad K Hassan
Sep 11, 2020·Anemia·Abdul-Wahab M Al-SaqladiAida H Al-Sadeeq
Mar 10, 2020·Complementary Therapies in Medicine·Samir K Ballas, Deepika S Darbari
Aug 20, 2021·Journal of Blood Medicine·Shereen M Abd El-GhanyBayan Y Almuzaini