Sickle cell trait (HbAS) and stunting in children below two years of age in an area of high malaria transmission.

Malaria Journal
Benno KreuelsJürgen May

Abstract

While the protective effects of sickle cell trait (HbAS) against severe malaria and the resulting survival advantage are well known, the impact on the physical development in young children remains unclear. This study was aimed to investigate the relationship between HbS carriage and stunting in children below two years of age in a cohort from the Ashanti Region, Ghana. 1,070 children were recruited at three months of age and followed-up for 21 months with anthropometric measurements performed every three months. Incidence rate ratios with 95% confidence intervals were calculated by Poisson regression to estimate the association of beta-globin genotypes with the number of malaria episodes. Odds ratios (OR) were calculated for the association between the occurrence of beta-globin genotypes and/or malaria episodes and stunting. The age-dependent between-group and within-group effects for the beta-globin genotypes were assessed by population-averaged models estimated by generalized estimation equation with autoregressive correlation structure. Analyses showed a significantly lower age-dependent risk of stunting (OR 0.56; 95% CI 0.33-0.96) in carriers of the HbAS genotype (n = 102) in comparison to those with HbAA (n = 692). This e...Continue Reading

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Citations

Aug 9, 2013·International Journal of Epidemiology·Hyunseung KangDylan S Small
Mar 19, 2014·The American Journal of Tropical Medicine and Hygiene·Becky L TsangParminder S Suchdev
Jan 1, 2012·International Quarterly of Community Health Education·S H IdrisA Abubakar
Aug 16, 2017·BMC Infectious Diseases·Kevin CrokeBruno P Mmbando

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Methods Mentioned

BETA
genotyping

Software Mentioned

STATA

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