Sickle Cell Trait Worsens Oxidative Stress, Abnormal Blood Rheology, and Vascular Dysfunction in Type 2 Diabetes

Diabetes Care
Mor DiawPhilippe Connes

Abstract

It is predicted that Africa will have the greatest increase in the number of patients with type 2 diabetes mellitus (T2DM) within the next decade. T2DM patients are at risk for cardiovascular disorders. In Sub-Saharan African countries, sickle cell trait (SCT) is frequent. Despite the presence of modest abnormalities in hemorheology and oxidative stress, SCT is generally considered a benign condition. Little is known about vascular function in SCT, although recent studies demonstrated an increased risk of cardiovascular disorders, including venous thromboembolism, stroke, and chronic kidney disease. We hypothesized that SCT could accentuate the vascular dysfunction observed in T2DM. The current study, conducted in Senegal, compared vascular function, hemorheological profile, and biomarkers of oxidative stress, inflammation, and nitric oxide metabolism in healthy individuals (CONT), subjects with T2DM or SCT, and patients with both T2DM and SCT (T2DM-SCT). Flow-mediated dilation was blunted in individuals with T2DM, SCT, and T2DM-SCT compared with CONT, with vascular dysfunction being most pronounced in the latter group. Carotid-femoral pulse wave velocity measurements demonstrated increased arterial stiffness in T2DM-SCT. Oxida...Continue Reading

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Citations

Apr 18, 2018·Clinical Hemorheology and Microcirculation·Valentin OuédraogoGeorges Lefthériotis
Mar 20, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Jordan LoaderMatthieu Roustit
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Dec 8, 2019·Journal of the American Society of Nephrology : JASN·Kabir O OlaniranSahir Kalim
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Mar 3, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Kabir O OlaniranSahir Kalim
Oct 12, 2021·European Journal of Applied Physiology·K ReminyS Antoine-Jonville

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BETA
MDA
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SPSS

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