Sickle hemoglobin oxygen affinity-shifting strategies have unequal cerebrovascular risks

Apr 19, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lori C Jordan, Michael R DeBaun

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Citations

5-(Hydroxymethyl)furfural restores low-oxygen rheology of sickle trait blood in vitro.

Jan 1, 2020·British Journal of Haematology·Scott HansenJohn M Higgins

Primary polymerization prevention.

Apr 27, 2019·Blood·Martin H Steinberg

White matter has impaired resting oxygen delivery in sickle cell patients.

Jan 31, 2019·American Journal of Hematology·Yaqiong ChaiJohn C Wood

Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease

Jun 13, 2020·Proceedings of the National Academy of Sciences of the United States of America·Eric R HenryWilliam A Eaton

Voxelotor (GBT440), a first-in-class hemoglobin oxygen-affinity modulator, has promising and reassuring preclinical and clinical data

Jan 21, 2018·American Journal of Hematology·Jeremie H Estepp

Recent Advances in the Treatment of Sickle Cell Disease

Jun 9, 2020·Frontiers in Physiology·Gabriel Salinas Cisneros, Swee L Thein

Systematic Review of Voxelotor: A First-in-Class Sickle Hemoglobin Polymerization Inhibitor for Management of Sickle Cell Disease.

Apr 29, 2020·Pharmacotherapy·Jin HanVictor R Gordeuk

Therapeutic strategies for sickle cell disease: towards a multi-agent approach

Dec 6, 2018·Nature Reviews. Drug Discovery·Marilyn J TelenGregory M Vercellotti

VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions.

Nov 22, 2020·Scientific Reports·Osheiza AbdulmalikMartin K Safo

Sickle cell disease: progress towards combination drug therapy.

Jan 21, 2021·British Journal of Haematology·Betty S PaceAbdullah Kutlar

Sulfated non-anticoagulant heparin derivative modifies intracellular hemoglobin, inhibits cell sickling in vitro, and prolongs survival of sickle cell mice under hypoxia.

Feb 12, 2021·Haematologica·Osheiza AbdulmalikShaker A Mousa

Voxelotor: alteration of sickle cell disease pathophysiology by a first-in-class polymerization inhibitor.

Apr 3, 2021·Therapeutic Advances in Hematology·Alexander K GlarosAhmar U Zaidi

Will the changing therapeutic landscape meet the needs of patients with sickle cell disease?

Apr 11, 2021·The Lancet. Haematology·Baba Psalm Duniya InusaNatasha Archer

MWC allosteric model explains unusual hemoglobin-oxygen binding curves from sickle cell drug binding.

May 2, 2021·Biophysical Journal·Eric R HenryWilliam A Eaton

Research in Sickle Cell Disease: From Bedside to Bench to Bedside.

Jun 8, 2021·HemaSphere·Gabriel Salinas Cisneros, Swee Lay Thein

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin.

Jul 2, 2021·Blood·Eric R HenryWilliam A Eaton

Increased oxygen affinity: to have and to hold.

Oct 1, 2021·Blood·Charles T Quinn, Russell E Ware

Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease.

Jan 16, 2022·The Journal of Pharmacology and Experimental Therapeutics·Patricia SchroederTheodosia A Kalfa

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Sickle hemoglobin oxygen affinity-shifting strategies have unequal cerebrovascular risks

Abstract

References

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GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease