Sickness behavior in birds caused by peripheral or central injection of endotoxin

Physiology & Behavior
R W JohnsonK W Kelley

Abstract

Recent evidence indicates that many of the physiologic, metabolic, and behavioral responses that accompany infection in mammals are important for maintaining homeostasis and promoting recovery. In the present report, we have extended this concept to birds by demonstrating that LPS injected IP reduces feed intake, increases somnolence, decreases plasma [Fe] and [Zn], increases plasma [Cu], and elevates plasma corticosterone. To determine if any of these effects could be mediated centrally, LPS was injected intracerebroventricularly (ICV). Whereas peripheral injection of LPS caused a modest increase in body temperature, the hyperthermic effect of LPS injected ICV was intense and long lasting. This hyperthermia following ICV injection of LPS was accompanied by only a transient reduction in food intake and elevation in somnolent activity, with no change in plasma [Fe] or [Zn]. Both peripheral and central injections of LPS increased plasma corticosterone, but the increase caused by peripherally administered LPS was sixfold higher than that caused by LPS injected centrally. Collectively, these data show that chickens respond to both peripheral and central injections of endotoxin by reducing food consumption, increasing somnolence, be...Continue Reading

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S KentJ L Vannice
Jan 1, 1992·Trends in Pharmacological Sciences·S KentR Dantzer
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E M SmithJ E Blalock
Dec 1, 1989·General and Comparative Endocrinology·R MeeuwisE R Kühn
Nov 29, 1985·Science·B M WoloskiJ E Blalock
Jan 1, 1988·Neuroscience and Biobehavioral Reviews·B L Hart
Jan 1, 1988·The International Journal of Neuroscience·C M Blatteis
May 31, 1974·Science·E D Weinberg
Jan 1, 1993·Physiology & Behavior·R W JohnsonK W Kelley
Apr 1, 1962·The Journal of Comparative Neurology·A VAN TIENHOVEN, L P JUHASZ

❮ Previous
Next ❯

Citations

Nov 20, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·David A GrayShane K Maloney
Apr 1, 1995·Physiology & Behavior·M S ExtonA J Husband
Oct 1, 1994·Veterinary Immunology and Immunopathology·K W KelleyR Dantzer
Aug 28, 2004·Brain, Behavior, and Immunity·Lisa M Schrott, Sheldon B Sparber
Apr 28, 2001·Pharmacology, Biochemistry, and Behavior·K M SellS Kent
Sep 24, 1999·Pharmacology, Biochemistry, and Behavior·L M SchrottS B Sparber
Mar 10, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·E A Koutsos, K C Klasing
Oct 28, 2005·Journal of Zhejiang University. Science. B·E GruysS J Koopmans
Nov 11, 2003·The Japanese Journal of Physiology·Shigeki Nomoto
May 3, 2011·Polish Journal of Veterinary Sciences·K Dudek, D Bednarek
Mar 25, 2011·Journal of Pharmacy & Bioallied Sciences·Sachin JainSania Naseem
Jun 20, 2014·Proceedings. Biological Sciences·Patricia C Lopes
Sep 1, 2009·Integrative and Comparative Biology·Angela M WynneJonathan P Godbout
Feb 3, 2015·American Journal of Physical Anthropology·Eric C Shattuck, Michael P Muehlenbein
May 18, 2016·Behavioural Processes·Ken SullivanShelley A Adamo
Jul 23, 2016·Mediators of Inflammation·Gustav van NiekerkAnna-Mart Engelbrecht
Aug 26, 1998·The Journal of Physiology·D A Gray, S K Maloney
Apr 8, 2017·Prostaglandins & Other Lipid Mediators·Tetsuya TachibanaMark A Cline
Sep 1, 2007·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Motamed Elsayed MahmoudTadashi Takewaki
Jan 1, 2013·Polish Journal of Veterinary Sciences·K DudekT Studziński
Jun 1, 1997·The American Journal of Physiology·L M GaetkeS I Shedlofsky
Jan 23, 2018·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Katie B NeedhamTimothy J Greives
Feb 12, 2014·Molecular Biology Reports·Chunyang SongYonggang Pang
Dec 15, 2020·British Poultry Science·T TachibanaM A Cline
Feb 19, 2008·The Journal of Experimental Biology·Jennifer L Grindstaff
Apr 28, 2021·Physiology & Behavior·Tetsuya TachibanaMark A Cline
Apr 21, 2021·Annals of the New York Academy of Sciences·Kelsey R MorenoYossi Yovel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.