PMID: 2510273Jan 1, 1989Paper

Side effects of anti-ulcer prostaglandins: an overview of the worldwide clinical experience

Scandinavian Journal of Gastroenterology. Supplement
G Bianchi Porro, F Parente

Abstract

Anti-ulcer prostaglandins (PG)--misoprostol, enprostil and rioprostil--have been given to more than 5000 patients in short-term studies on gastric and duodenal ulcer. Analysis of these studies shows the drugs to be safe. Their side effects appear to be dose-dependent and mainly restricted to the gastrointestinal system, the major syndromes being diarrhoea and abdominal pain. The clinical relevance of PG-related unwanted effects, though in average exceeding that of H2-blockers, seems to be sufficiently low. In terms of safety efficacy, however, they appear inferior to H2-antagonists, so their routine use in preference to the latter compounds is still premature.

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Citations

Feb 1, 1995·Digestive Diseases and Sciences·R A SmallwoodA Parkinson
Feb 23, 2008·Pharmaceutical Research·Tsutomu IshiharaYutaka Mizushima
Nov 15, 1997·Scandinavian Journal of Gastroenterology·J W KonturekW Domschke
Mar 1, 1992·American Journal of Surgery·K D Katz, D Hollander
Mar 23, 2017·European Journal of Pharmacology·Kelvin K W KanJohn A Rudd

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